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No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women
Breast cancer is the most frequent malignancy affecting women worldwide. It has been suggested that infection by Epstein Barr Virus (EBV), Mouse Mammary Tumor Virus or a similar virus, MMTV-like virus (MMTV-LV), play a role in the etiology of the disease. However, studies looking at the presence of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797988/ https://www.ncbi.nlm.nih.gov/pubmed/24131889 http://dx.doi.org/10.1038/srep02970 |
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author | Morales-Sánchez, Abigail Molina-Muñoz, Tzindilú Martínez-López, Juan L. E. Hernández-Sancén, Paulina Mantilla, Alejandra Leal, Yelda A. Torres, Javier Fuentes-Pananá, Ezequiel M. |
author_facet | Morales-Sánchez, Abigail Molina-Muñoz, Tzindilú Martínez-López, Juan L. E. Hernández-Sancén, Paulina Mantilla, Alejandra Leal, Yelda A. Torres, Javier Fuentes-Pananá, Ezequiel M. |
author_sort | Morales-Sánchez, Abigail |
collection | PubMed |
description | Breast cancer is the most frequent malignancy affecting women worldwide. It has been suggested that infection by Epstein Barr Virus (EBV), Mouse Mammary Tumor Virus or a similar virus, MMTV-like virus (MMTV-LV), play a role in the etiology of the disease. However, studies looking at the presence of these viruses in breast cancer have produced conflicting results, and this possible association remains controversial. Here, we used polymerase chain reaction assay to screen specific sequences of EBV and MMTV-LV in 86 tumor and 65 adjacent tissues from Mexican women with breast cancer. Neither tumor samples nor adjacent tissue were positive for either virus in a first round PCR and only 4 tumor samples were EBV positive by a more sensitive nested PCR. Considering the study's statistical power, these results do not support the involvement of EBV and MMTV-LV in the etiology of breast cancer. |
format | Online Article Text |
id | pubmed-3797988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37979882013-10-18 No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women Morales-Sánchez, Abigail Molina-Muñoz, Tzindilú Martínez-López, Juan L. E. Hernández-Sancén, Paulina Mantilla, Alejandra Leal, Yelda A. Torres, Javier Fuentes-Pananá, Ezequiel M. Sci Rep Article Breast cancer is the most frequent malignancy affecting women worldwide. It has been suggested that infection by Epstein Barr Virus (EBV), Mouse Mammary Tumor Virus or a similar virus, MMTV-like virus (MMTV-LV), play a role in the etiology of the disease. However, studies looking at the presence of these viruses in breast cancer have produced conflicting results, and this possible association remains controversial. Here, we used polymerase chain reaction assay to screen specific sequences of EBV and MMTV-LV in 86 tumor and 65 adjacent tissues from Mexican women with breast cancer. Neither tumor samples nor adjacent tissue were positive for either virus in a first round PCR and only 4 tumor samples were EBV positive by a more sensitive nested PCR. Considering the study's statistical power, these results do not support the involvement of EBV and MMTV-LV in the etiology of breast cancer. Nature Publishing Group 2013-10-17 /pmc/articles/PMC3797988/ /pubmed/24131889 http://dx.doi.org/10.1038/srep02970 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Morales-Sánchez, Abigail Molina-Muñoz, Tzindilú Martínez-López, Juan L. E. Hernández-Sancén, Paulina Mantilla, Alejandra Leal, Yelda A. Torres, Javier Fuentes-Pananá, Ezequiel M. No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title | No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title_full | No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title_fullStr | No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title_full_unstemmed | No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title_short | No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women |
title_sort | no association between epstein-barr virus and mouse mammary tumor virus with breast cancer in mexican women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797988/ https://www.ncbi.nlm.nih.gov/pubmed/24131889 http://dx.doi.org/10.1038/srep02970 |
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