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Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mi...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797990/ https://www.ncbi.nlm.nih.gov/pubmed/24131900 http://dx.doi.org/10.1038/srep02973 |
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author | Sugita, Kazunari Ikenouchi-Sugita, Atsuko Nakayama, Yasuko Yoshioka, Haruna Nomura, Takashi Sakabe, Jun-ichi Nakahigashi, Kyoko Kuroda, Etsushi Uematsu, Satoshi Nakamura, Jun Akira, Shizuo Nakamura, Motonobu Narumiya, Shuh Miyachi, Yoshiki Tokura, Yoshiki Kabashima, Kenji |
author_facet | Sugita, Kazunari Ikenouchi-Sugita, Atsuko Nakayama, Yasuko Yoshioka, Haruna Nomura, Takashi Sakabe, Jun-ichi Nakahigashi, Kyoko Kuroda, Etsushi Uematsu, Satoshi Nakamura, Jun Akira, Shizuo Nakamura, Motonobu Narumiya, Shuh Miyachi, Yoshiki Tokura, Yoshiki Kabashima, Kenji |
author_sort | Sugita, Kazunari |
collection | PubMed |
description | Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE(2) production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE(2) production via induction of ROS formation. |
format | Online Article Text |
id | pubmed-3797990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37979902013-10-18 Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production Sugita, Kazunari Ikenouchi-Sugita, Atsuko Nakayama, Yasuko Yoshioka, Haruna Nomura, Takashi Sakabe, Jun-ichi Nakahigashi, Kyoko Kuroda, Etsushi Uematsu, Satoshi Nakamura, Jun Akira, Shizuo Nakamura, Motonobu Narumiya, Shuh Miyachi, Yoshiki Tokura, Yoshiki Kabashima, Kenji Sci Rep Article Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE(2) production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE(2) production via induction of ROS formation. Nature Publishing Group 2013-10-17 /pmc/articles/PMC3797990/ /pubmed/24131900 http://dx.doi.org/10.1038/srep02973 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Sugita, Kazunari Ikenouchi-Sugita, Atsuko Nakayama, Yasuko Yoshioka, Haruna Nomura, Takashi Sakabe, Jun-ichi Nakahigashi, Kyoko Kuroda, Etsushi Uematsu, Satoshi Nakamura, Jun Akira, Shizuo Nakamura, Motonobu Narumiya, Shuh Miyachi, Yoshiki Tokura, Yoshiki Kabashima, Kenji Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title | Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title_full | Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title_fullStr | Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title_full_unstemmed | Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title_short | Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production |
title_sort | prostaglandin e(2) is critical for the development of niacin-deficiency-induced photosensitivity via ros production |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797990/ https://www.ncbi.nlm.nih.gov/pubmed/24131900 http://dx.doi.org/10.1038/srep02973 |
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