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Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mi...

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Autores principales: Sugita, Kazunari, Ikenouchi-Sugita, Atsuko, Nakayama, Yasuko, Yoshioka, Haruna, Nomura, Takashi, Sakabe, Jun-ichi, Nakahigashi, Kyoko, Kuroda, Etsushi, Uematsu, Satoshi, Nakamura, Jun, Akira, Shizuo, Nakamura, Motonobu, Narumiya, Shuh, Miyachi, Yoshiki, Tokura, Yoshiki, Kabashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797990/
https://www.ncbi.nlm.nih.gov/pubmed/24131900
http://dx.doi.org/10.1038/srep02973
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author Sugita, Kazunari
Ikenouchi-Sugita, Atsuko
Nakayama, Yasuko
Yoshioka, Haruna
Nomura, Takashi
Sakabe, Jun-ichi
Nakahigashi, Kyoko
Kuroda, Etsushi
Uematsu, Satoshi
Nakamura, Jun
Akira, Shizuo
Nakamura, Motonobu
Narumiya, Shuh
Miyachi, Yoshiki
Tokura, Yoshiki
Kabashima, Kenji
author_facet Sugita, Kazunari
Ikenouchi-Sugita, Atsuko
Nakayama, Yasuko
Yoshioka, Haruna
Nomura, Takashi
Sakabe, Jun-ichi
Nakahigashi, Kyoko
Kuroda, Etsushi
Uematsu, Satoshi
Nakamura, Jun
Akira, Shizuo
Nakamura, Motonobu
Narumiya, Shuh
Miyachi, Yoshiki
Tokura, Yoshiki
Kabashima, Kenji
author_sort Sugita, Kazunari
collection PubMed
description Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE(2) production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE(2) production via induction of ROS formation.
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spelling pubmed-37979902013-10-18 Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production Sugita, Kazunari Ikenouchi-Sugita, Atsuko Nakayama, Yasuko Yoshioka, Haruna Nomura, Takashi Sakabe, Jun-ichi Nakahigashi, Kyoko Kuroda, Etsushi Uematsu, Satoshi Nakamura, Jun Akira, Shizuo Nakamura, Motonobu Narumiya, Shuh Miyachi, Yoshiki Tokura, Yoshiki Kabashima, Kenji Sci Rep Article Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE(2) production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE(2) production via induction of ROS formation. Nature Publishing Group 2013-10-17 /pmc/articles/PMC3797990/ /pubmed/24131900 http://dx.doi.org/10.1038/srep02973 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Sugita, Kazunari
Ikenouchi-Sugita, Atsuko
Nakayama, Yasuko
Yoshioka, Haruna
Nomura, Takashi
Sakabe, Jun-ichi
Nakahigashi, Kyoko
Kuroda, Etsushi
Uematsu, Satoshi
Nakamura, Jun
Akira, Shizuo
Nakamura, Motonobu
Narumiya, Shuh
Miyachi, Yoshiki
Tokura, Yoshiki
Kabashima, Kenji
Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title_full Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title_fullStr Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title_full_unstemmed Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title_short Prostaglandin E(2) is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
title_sort prostaglandin e(2) is critical for the development of niacin-deficiency-induced photosensitivity via ros production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797990/
https://www.ncbi.nlm.nih.gov/pubmed/24131900
http://dx.doi.org/10.1038/srep02973
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