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Drug Rescue Distinguishes between Different Structural Models of Human P-Glycoprotein
[Image: see text] There is no high-resolution crystal structure of the human P-glycoprotein (P-gp) drug pump. Homology models of human P-gp based on the crystal structures of mouse or Caenorhabditis elegans P-gps show large differences in the orientation of transmembrane segment 5 (TM5). TM5 is one...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798097/ https://www.ncbi.nlm.nih.gov/pubmed/24083983 http://dx.doi.org/10.1021/bi401269m |