Cargando…

Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue

BACKGROUND: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or inhibition of either metabolic enzymes or efflux transporters. OBJECTIVE: The effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Carien, Beneke, Alvaro, Viljoen, Josias, Hamman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798139/
https://www.ncbi.nlm.nih.gov/pubmed/24143044
http://dx.doi.org/10.4103/0973-1296.117864
_version_ 1782287722429284352
author Carien, Beneke
Alvaro, Viljoen
Josias, Hamman
author_facet Carien, Beneke
Alvaro, Viljoen
Josias, Hamman
author_sort Carien, Beneke
collection PubMed
description BACKGROUND: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or inhibition of either metabolic enzymes or efflux transporters. OBJECTIVE: The effect of gel and whole leaf materials from 3 different aloe species namely Aloe ferox, Aloe marlothii, and Aloe vera as well as polysaccharides precipitated from the A. vera materials on the bi-directional transport of cimetidine across rat intestinal tissue was investigated. MATERIALS AND METHODS: Cimetidine transport studies were performed across excised rat intestinal tissue mounted in Sweetana-Grass diffusion chambers in both the apical-to-basolateral and basolateral-to-apical directions. RESULTS: While A. vera gel and whole leaf materials did not inhibit the efflux of cimetidine, the polysaccharides precipitated from them did show a reduction of cimetidine efflux. On the other hand, both A. ferox and A. marlothii gel and whole leaf materials exhibited an inhibition effect on cimetidine efflux. CONCLUSIONS: This study identified a modulation effect of efflux transporters by certain aloe materials. This may cause herb-drug pharmacokinetic interactions when drugs that are substrates for these efflux transporters are taken simultaneously with aloe materials. On the other hand, these aloe materials may be used for drug absorption enhancement for drugs with low bioavailability due to extensive efflux.
format Online
Article
Text
id pubmed-3798139
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37981392013-10-18 Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue Carien, Beneke Alvaro, Viljoen Josias, Hamman Pharmacogn Mag Original Article BACKGROUND: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or inhibition of either metabolic enzymes or efflux transporters. OBJECTIVE: The effect of gel and whole leaf materials from 3 different aloe species namely Aloe ferox, Aloe marlothii, and Aloe vera as well as polysaccharides precipitated from the A. vera materials on the bi-directional transport of cimetidine across rat intestinal tissue was investigated. MATERIALS AND METHODS: Cimetidine transport studies were performed across excised rat intestinal tissue mounted in Sweetana-Grass diffusion chambers in both the apical-to-basolateral and basolateral-to-apical directions. RESULTS: While A. vera gel and whole leaf materials did not inhibit the efflux of cimetidine, the polysaccharides precipitated from them did show a reduction of cimetidine efflux. On the other hand, both A. ferox and A. marlothii gel and whole leaf materials exhibited an inhibition effect on cimetidine efflux. CONCLUSIONS: This study identified a modulation effect of efflux transporters by certain aloe materials. This may cause herb-drug pharmacokinetic interactions when drugs that are substrates for these efflux transporters are taken simultaneously with aloe materials. On the other hand, these aloe materials may be used for drug absorption enhancement for drugs with low bioavailability due to extensive efflux. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3798139/ /pubmed/24143044 http://dx.doi.org/10.4103/0973-1296.117864 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Carien, Beneke
Alvaro, Viljoen
Josias, Hamman
Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title_full Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title_fullStr Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title_full_unstemmed Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title_short Modulation of drug efflux by aloe materials: An In Vitro investigation across rat intestinal tissue
title_sort modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798139/
https://www.ncbi.nlm.nih.gov/pubmed/24143044
http://dx.doi.org/10.4103/0973-1296.117864
work_keys_str_mv AT carienbeneke modulationofdrugeffluxbyaloematerialsaninvitroinvestigationacrossratintestinaltissue
AT alvaroviljoen modulationofdrugeffluxbyaloematerialsaninvitroinvestigationacrossratintestinaltissue
AT josiashamman modulationofdrugeffluxbyaloematerialsaninvitroinvestigationacrossratintestinaltissue