The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells

Exploitation of embryonic stem cells (ESC) for therapeutic use and biomedical applications is severely hampered by the risk of teratocarcinoma formation. Here, we performed a screen of selected epi-modulating compounds and demonstrate that a transient exposure of mouse ESC to MS-275 (Entinostat), a...

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Detalles Bibliográficos
Autores principales: Franci, Gianluigi, Casalino, Laura, Petraglia, Francesca, Miceli, Marco, Menafra, Roberta, Radic, Branka, Tarallo, Valeria, Vitale, Monica, Scarfò, Marzia, Pocsfalvi, Gabriella, Baldi, Alfonso, Ambrosino, Concetta, Zambrano, Nicola, Patriarca, Eduardo, De Falco, Sandro, Minchiotti, Gabriella, Stunnenberg, Hendrik G., Altucci, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798190/
https://www.ncbi.nlm.nih.gov/pubmed/24167717
http://dx.doi.org/10.1242/bio.20135587

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