Nonrandom template segregation: A way to break the symmetry of stem cells

Whether DNA segregates in a biased way has been a subject of intense controversy and debate. Although highly provocative in its biological implications, if true, technical problems have limited researchers from drawing firm conclusions from the data. Elabd et al. (2013. J. Cell Biol. http://dx.doi.o...

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Autor principal: Yamashita, Yukiko M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798250/
https://www.ncbi.nlm.nih.gov/pubmed/24127212
http://dx.doi.org/10.1083/jcb.201308110
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author Yamashita, Yukiko M.
author_facet Yamashita, Yukiko M.
author_sort Yamashita, Yukiko M.
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description Whether DNA segregates in a biased way has been a subject of intense controversy and debate. Although highly provocative in its biological implications, if true, technical problems have limited researchers from drawing firm conclusions from the data. Elabd et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201307110/DC1) now show a high frequency of nonrandom template segregation during differentiation of embryonic stem cells using rigorous experimentation and implicate the methyltransferase Dnmt3 as a key regulator of this process.
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spelling pubmed-37982502014-04-14 Nonrandom template segregation: A way to break the symmetry of stem cells Yamashita, Yukiko M. J Cell Biol Reviews Whether DNA segregates in a biased way has been a subject of intense controversy and debate. Although highly provocative in its biological implications, if true, technical problems have limited researchers from drawing firm conclusions from the data. Elabd et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201307110/DC1) now show a high frequency of nonrandom template segregation during differentiation of embryonic stem cells using rigorous experimentation and implicate the methyltransferase Dnmt3 as a key regulator of this process. The Rockefeller University Press 2013-10-14 /pmc/articles/PMC3798250/ /pubmed/24127212 http://dx.doi.org/10.1083/jcb.201308110 Text en © 2013 Yamashita This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Yamashita, Yukiko M.
Nonrandom template segregation: A way to break the symmetry of stem cells
title Nonrandom template segregation: A way to break the symmetry of stem cells
title_full Nonrandom template segregation: A way to break the symmetry of stem cells
title_fullStr Nonrandom template segregation: A way to break the symmetry of stem cells
title_full_unstemmed Nonrandom template segregation: A way to break the symmetry of stem cells
title_short Nonrandom template segregation: A way to break the symmetry of stem cells
title_sort nonrandom template segregation: a way to break the symmetry of stem cells
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798250/
https://www.ncbi.nlm.nih.gov/pubmed/24127212
http://dx.doi.org/10.1083/jcb.201308110
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