miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanin...

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Detalles Bibliográficos
Autores principales: Quintavalle, Cristina, Mangani, Davide, Roscigno, Giuseppina, Romano, Giulia, Diaz-Lagares, Angel, Iaboni, Margherita, Donnarumma, Elvira, Fiore, Danilo, De Marinis, Pasqualino, Soini, Ylermi, Esteller, Manel, Condorelli, Gerolama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798259/
https://www.ncbi.nlm.nih.gov/pubmed/24147153
http://dx.doi.org/10.1371/journal.pone.0074466

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