Yeast Tdh3 (Glyceraldehyde 3-Phosphate Dehydrogenase) Is a Sir2-Interacting Factor That Regulates Transcriptional Silencing and rDNA Recombination

Sir2 is an NAD(+)-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH), as a high expression suppressor of the lethality caused by Sir2 overexpre...

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Detalles Bibliográficos
Autores principales: Ringel, Alison E., Ryznar, Rebecca, Picariello, Hannah, Huang, Kuan-lin, Lazarus, Asmitha G., Holmes, Scott G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798266/
https://www.ncbi.nlm.nih.gov/pubmed/24146631
http://dx.doi.org/10.1371/journal.pgen.1003871

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