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Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway

The proinflammatory cytokine IL-1β is a key mediator of inflammatory responses that contribute to and exacerbate brain injury. IL-1β is synthesized by microglia in the brain as an inactive precursor (pro-IL-1β). Cleavage of pro-IL-1β to a mature form is stimulated by damage-associated molecular patt...

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Detalles Bibliográficos
Autores principales:	Edye, Michelle E., Lopez-Castejon, Gloria, Allan, Stuart M., Brough, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798512/ https://www.ncbi.nlm.nih.gov/pubmed/24022484 http://dx.doi.org/10.1074/jbc.M113.478941

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