The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes

HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC membrane results in low level de novo infection t...

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Detalles Bibliográficos
Autores principales: Mercier, Sarah K., Donaghy, Heather, Botting, Rachel A., Turville, Stuart G., Harman, Andrew N., Nasr, Najla, Ji, Hong, Kusebauch, Ulrike, Mendoza, Luis, Shteynberg, David, Sandgren, Kerrie, Simpson, Richard J., Moritz, Robert L., Cunningham, Anthony L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798598/
https://www.ncbi.nlm.nih.gov/pubmed/24204260
http://dx.doi.org/10.1371/journal.ppat.1003700

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