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Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients
OBJECTIVES: To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. METHOD: In total, 42 American Society of Anesthesiologists physical status class I-II female patients...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798610/ https://www.ncbi.nlm.nih.gov/pubmed/24212836 http://dx.doi.org/10.6061/clinics/2013(10)03 |
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author | Lin, Tso-Chou Lu, Chih-Cherng Hsu, Che-Hao Wu, Gwo-Jang Lee, Meei-Shyuan Ho, Shung-Tai |
author_facet | Lin, Tso-Chou Lu, Chih-Cherng Hsu, Che-Hao Wu, Gwo-Jang Lee, Meei-Shyuan Ho, Shung-Tai |
author_sort | Lin, Tso-Chou |
collection | PubMed |
description | OBJECTIVES: To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. METHOD: In total, 42 American Society of Anesthesiologists physical status class I-II female patients undergoing elective gynecologic surgery were enrolled. General anesthesia was maintained with fixed 6% inspiratory desflurane in 6 l min(-1) oxygen until shutoff of the vaporizer at the end of surgery. One milliliter of arterial blood was obtained for desflurane concentration determination by gas chromatography at 20 and 10 minutes before and 0, 5, 10, 15, and 20 minutes after the discontinuation of desflurane and at the time of eye opening upon verbal command, defined as awakening. Concentrations of inspiratory and end-tidal desflurane were simultaneously detected by an infrared analyzer. RESULTS: The mean arterial blood concentration of desflurane was 1.20% at awakening, which correlated with the awakening end-tidal concentration of 0.96%. The mean time from the discontinuation of desflurane to eye opening was 5.2 minutes (SD = 1.6, range 3-10), which was not associated with the duration of anesthesia (60-256 minutes), total fentanyl dose, or body mass index (BMI). CONCLUSIONS: The mean awakening arterial blood concentration of desflurane was 1.20%. The time to awakening was independent of anesthetic duration within four hours. Using well-assisted ventilation, the end-tidal concentration of desflurane was proven to represent the arterial blood concentration during elimination and could be a clinically feasible predictor of emergence from general anesthesia. |
format | Online Article Text |
id | pubmed-3798610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-37986102013-10-22 Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients Lin, Tso-Chou Lu, Chih-Cherng Hsu, Che-Hao Wu, Gwo-Jang Lee, Meei-Shyuan Ho, Shung-Tai Clinics (Sao Paulo) Clinical Science OBJECTIVES: To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. METHOD: In total, 42 American Society of Anesthesiologists physical status class I-II female patients undergoing elective gynecologic surgery were enrolled. General anesthesia was maintained with fixed 6% inspiratory desflurane in 6 l min(-1) oxygen until shutoff of the vaporizer at the end of surgery. One milliliter of arterial blood was obtained for desflurane concentration determination by gas chromatography at 20 and 10 minutes before and 0, 5, 10, 15, and 20 minutes after the discontinuation of desflurane and at the time of eye opening upon verbal command, defined as awakening. Concentrations of inspiratory and end-tidal desflurane were simultaneously detected by an infrared analyzer. RESULTS: The mean arterial blood concentration of desflurane was 1.20% at awakening, which correlated with the awakening end-tidal concentration of 0.96%. The mean time from the discontinuation of desflurane to eye opening was 5.2 minutes (SD = 1.6, range 3-10), which was not associated with the duration of anesthesia (60-256 minutes), total fentanyl dose, or body mass index (BMI). CONCLUSIONS: The mean awakening arterial blood concentration of desflurane was 1.20%. The time to awakening was independent of anesthetic duration within four hours. Using well-assisted ventilation, the end-tidal concentration of desflurane was proven to represent the arterial blood concentration during elimination and could be a clinically feasible predictor of emergence from general anesthesia. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2013-10 /pmc/articles/PMC3798610/ /pubmed/24212836 http://dx.doi.org/10.6061/clinics/2013(10)03 Text en Copyright © 2013 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science Lin, Tso-Chou Lu, Chih-Cherng Hsu, Che-Hao Wu, Gwo-Jang Lee, Meei-Shyuan Ho, Shung-Tai Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title | Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title_full | Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title_fullStr | Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title_full_unstemmed | Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title_short | Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
title_sort | duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798610/ https://www.ncbi.nlm.nih.gov/pubmed/24212836 http://dx.doi.org/10.6061/clinics/2013(10)03 |
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