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Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA

LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANA(DBD)) to reveal its capacity to form a decameric ring with an exterior DNA bindi...

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Detalles Bibliográficos
Autores principales:	Domsic, John F., Chen, Horng-Shen, Lu, Fang, Marmorstein, Ronen, Lieberman, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798644/ https://www.ncbi.nlm.nih.gov/pubmed/24146617 http://dx.doi.org/10.1371/journal.ppat.1003672

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