Genotoxicity induced by iodine-131 in human cultured lymphocytes

131-radioiodine has been widely used as an effective radionuclide for treatment of patients with thyroid diseases. The purpose of this study was to investigate the genotoxic effects of iodine-131 in human cultured lymphocytes. Whole blood samples from human volunteers were incubated with iodine-131...

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Detalles Bibliográficos
Autores principales: Hosseinimehr, Seyed Jalal, Shafaghati, Nayereh, Hedayati, Monireh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798859/
https://www.ncbi.nlm.nih.gov/pubmed/24179432
http://dx.doi.org/10.2478/intox-2013-0013
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author Hosseinimehr, Seyed Jalal
Shafaghati, Nayereh
Hedayati, Monireh
author_facet Hosseinimehr, Seyed Jalal
Shafaghati, Nayereh
Hedayati, Monireh
author_sort Hosseinimehr, Seyed Jalal
collection PubMed
description 131-radioiodine has been widely used as an effective radionuclide for treatment of patients with thyroid diseases. The purpose of this study was to investigate the genotoxic effects of iodine-131 in human cultured lymphocytes. Whole blood samples from human volunteers were incubated with iodine-131 (10, 50, 100 µCi/1.5ml) for 2 h. The lymphocytes were mitogenically stimulated to allow for evaluation of the number of micronuclei in cytokinesis-blocked binucleated cells. At the dose 100 µCi, iodine-131 induced genotoxicity by an 8.5 fold increase in the frequency of micronuclei in human lymphocytes compared with the control group.
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spelling pubmed-37988592013-10-31 Genotoxicity induced by iodine-131 in human cultured lymphocytes Hosseinimehr, Seyed Jalal Shafaghati, Nayereh Hedayati, Monireh Interdiscip Toxicol Original Article 131-radioiodine has been widely used as an effective radionuclide for treatment of patients with thyroid diseases. The purpose of this study was to investigate the genotoxic effects of iodine-131 in human cultured lymphocytes. Whole blood samples from human volunteers were incubated with iodine-131 (10, 50, 100 µCi/1.5ml) for 2 h. The lymphocytes were mitogenically stimulated to allow for evaluation of the number of micronuclei in cytokinesis-blocked binucleated cells. At the dose 100 µCi, iodine-131 induced genotoxicity by an 8.5 fold increase in the frequency of micronuclei in human lymphocytes compared with the control group. Slovak Toxicology Society SETOX 2013-06 2013-06 /pmc/articles/PMC3798859/ /pubmed/24179432 http://dx.doi.org/10.2478/intox-2013-0013 Text en Copyright © 2013 Slovak Toxicology Society SETOX http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hosseinimehr, Seyed Jalal
Shafaghati, Nayereh
Hedayati, Monireh
Genotoxicity induced by iodine-131 in human cultured lymphocytes
title Genotoxicity induced by iodine-131 in human cultured lymphocytes
title_full Genotoxicity induced by iodine-131 in human cultured lymphocytes
title_fullStr Genotoxicity induced by iodine-131 in human cultured lymphocytes
title_full_unstemmed Genotoxicity induced by iodine-131 in human cultured lymphocytes
title_short Genotoxicity induced by iodine-131 in human cultured lymphocytes
title_sort genotoxicity induced by iodine-131 in human cultured lymphocytes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798859/
https://www.ncbi.nlm.nih.gov/pubmed/24179432
http://dx.doi.org/10.2478/intox-2013-0013
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