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Arsenic toxicosis in sheep: The first report from Iran
Arsenic contamination of groundwater has been previously reported in Ghopuz, a village located in the Northwest of Iran. Samples were taken from consuming and irrigation water and plants of the region for chemical analysis. A seven-year old ewe, which had lived in and fed a lifelong at the same plac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Slovak Toxicology Society SETOX
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798862/ https://www.ncbi.nlm.nih.gov/pubmed/24179435 http://dx.doi.org/10.2478/intox-2013-0016 |
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author | Ashrafihelan, Javad Amoli, Jamileh Salar Alamdari, Mehran Esfahani, Tahereh Ali Mozafari, Morteza Nourian, Ali Reza Bahari, Ali Asghar |
author_facet | Ashrafihelan, Javad Amoli, Jamileh Salar Alamdari, Mehran Esfahani, Tahereh Ali Mozafari, Morteza Nourian, Ali Reza Bahari, Ali Asghar |
author_sort | Ashrafihelan, Javad |
collection | PubMed |
description | Arsenic contamination of groundwater has been previously reported in Ghopuz, a village located in the Northwest of Iran. Samples were taken from consuming and irrigation water and plants of the region for chemical analysis. A seven-year old ewe, which had lived in and fed a lifelong at the same place, with clinical signs such as weakness, wasting and inappropriate integument was necropsied. Grossly, buccal erosion, stomatitis, cutaneous ulcers and serous atrophy of fat deposits were observed. Rumen contents, wool and several tissue samples were obtained for toxicological and histopathological examinations. Mean arsenic concentration in the spring water, irrigation water and grass/algae were 70.11, 48.74 and 141.85 ppb (µg/kg), respectively. Arsenic levels were 486.73, 247.94, 127.92, 125.97 and 231.24 ppb in wool, skin, rumen contents, liver and kidney, respectively. Microscopic study revealed hyperemia and heavy parasitic infestation of the abomasal wall. Hyperemia and regeneration of renal tubule epithelia were observed in kidneys and hyperkeratosis, suppurative deep dermatitis and paniculitis were found in skin. Periacinar fibrosis and a poorly differentiated cholangiocarcinoma were seen in liver. In pancreas, reduced cell density of islands of Langerhans was noticeable. In the central nervous system, perineuronal and perivascular edema, ischemic changes in gray matter neurons, and microcavitation of white matter were present. Our findings confirmed chronic arsenic toxicosis in small ruminants in this region. It can be concluded that long-term consumption of arsenic contamined water and forage may be associated with chronic arsenic poisoning in domestic animals and human beings, with consequent neoplastic disease and induction of diabetes in this region. |
format | Online Article Text |
id | pubmed-3798862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-37988622013-10-31 Arsenic toxicosis in sheep: The first report from Iran Ashrafihelan, Javad Amoli, Jamileh Salar Alamdari, Mehran Esfahani, Tahereh Ali Mozafari, Morteza Nourian, Ali Reza Bahari, Ali Asghar Interdiscip Toxicol Original Article Arsenic contamination of groundwater has been previously reported in Ghopuz, a village located in the Northwest of Iran. Samples were taken from consuming and irrigation water and plants of the region for chemical analysis. A seven-year old ewe, which had lived in and fed a lifelong at the same place, with clinical signs such as weakness, wasting and inappropriate integument was necropsied. Grossly, buccal erosion, stomatitis, cutaneous ulcers and serous atrophy of fat deposits were observed. Rumen contents, wool and several tissue samples were obtained for toxicological and histopathological examinations. Mean arsenic concentration in the spring water, irrigation water and grass/algae were 70.11, 48.74 and 141.85 ppb (µg/kg), respectively. Arsenic levels were 486.73, 247.94, 127.92, 125.97 and 231.24 ppb in wool, skin, rumen contents, liver and kidney, respectively. Microscopic study revealed hyperemia and heavy parasitic infestation of the abomasal wall. Hyperemia and regeneration of renal tubule epithelia were observed in kidneys and hyperkeratosis, suppurative deep dermatitis and paniculitis were found in skin. Periacinar fibrosis and a poorly differentiated cholangiocarcinoma were seen in liver. In pancreas, reduced cell density of islands of Langerhans was noticeable. In the central nervous system, perineuronal and perivascular edema, ischemic changes in gray matter neurons, and microcavitation of white matter were present. Our findings confirmed chronic arsenic toxicosis in small ruminants in this region. It can be concluded that long-term consumption of arsenic contamined water and forage may be associated with chronic arsenic poisoning in domestic animals and human beings, with consequent neoplastic disease and induction of diabetes in this region. Slovak Toxicology Society SETOX 2013-06 2013-06 /pmc/articles/PMC3798862/ /pubmed/24179435 http://dx.doi.org/10.2478/intox-2013-0016 Text en Copyright © 2013 Slovak Toxicology Society SETOX http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ashrafihelan, Javad Amoli, Jamileh Salar Alamdari, Mehran Esfahani, Tahereh Ali Mozafari, Morteza Nourian, Ali Reza Bahari, Ali Asghar Arsenic toxicosis in sheep: The first report from Iran |
title | Arsenic toxicosis in sheep: The first report from Iran |
title_full | Arsenic toxicosis in sheep: The first report from Iran |
title_fullStr | Arsenic toxicosis in sheep: The first report from Iran |
title_full_unstemmed | Arsenic toxicosis in sheep: The first report from Iran |
title_short | Arsenic toxicosis in sheep: The first report from Iran |
title_sort | arsenic toxicosis in sheep: the first report from iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798862/ https://www.ncbi.nlm.nih.gov/pubmed/24179435 http://dx.doi.org/10.2478/intox-2013-0016 |
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