Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion

Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activ...

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Autores principales: Kubatzky, Katharina F., Kloos, Bianca, Hildebrand, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798879/
https://www.ncbi.nlm.nih.gov/pubmed/24064721
http://dx.doi.org/10.3390/toxins5091664
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author Kubatzky, Katharina F.
Kloos, Bianca
Hildebrand, Dagmar
author_facet Kubatzky, Katharina F.
Kloos, Bianca
Hildebrand, Dagmar
author_sort Kubatzky, Katharina F.
collection PubMed
description Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel.
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spelling pubmed-37988792013-10-21 Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion Kubatzky, Katharina F. Kloos, Bianca Hildebrand, Dagmar Toxins (Basel) Review Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel. MDPI 2013-09-24 /pmc/articles/PMC3798879/ /pubmed/24064721 http://dx.doi.org/10.3390/toxins5091664 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kubatzky, Katharina F.
Kloos, Bianca
Hildebrand, Dagmar
Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title_full Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title_fullStr Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title_full_unstemmed Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title_short Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
title_sort signaling cascades of pasteurella multocida toxin in immune evasion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798879/
https://www.ncbi.nlm.nih.gov/pubmed/24064721
http://dx.doi.org/10.3390/toxins5091664
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