Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection

Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector func...

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Detalles Bibliográficos
Autores principales: Wang, Tian, Welte, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798903/
https://www.ncbi.nlm.nih.gov/pubmed/24061543
http://dx.doi.org/10.3390/v5092298
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author Wang, Tian
Welte, Thomas
author_facet Wang, Tian
Welte, Thomas
author_sort Wang, Tian
collection PubMed
description Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector functions, accumulating evidence in mice and humans suggest these two cell types have distinct roles in the control of infection by West Nile virus (WNV), a re-emerging pathogen that has caused fatal encephalitis in North America over the past decade. This review will discuss recent studies on these two cell types in protective immunity and viral pathogenesis during WNV infection.
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spelling pubmed-37989032013-10-21 Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection Wang, Tian Welte, Thomas Viruses Review Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector functions, accumulating evidence in mice and humans suggest these two cell types have distinct roles in the control of infection by West Nile virus (WNV), a re-emerging pathogen that has caused fatal encephalitis in North America over the past decade. This review will discuss recent studies on these two cell types in protective immunity and viral pathogenesis during WNV infection. MDPI 2013-09-20 /pmc/articles/PMC3798903/ /pubmed/24061543 http://dx.doi.org/10.3390/v5092298 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wang, Tian
Welte, Thomas
Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title_full Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title_fullStr Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title_full_unstemmed Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title_short Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
title_sort role of natural killer and gamma-delta t cells in west nile virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798903/
https://www.ncbi.nlm.nih.gov/pubmed/24061543
http://dx.doi.org/10.3390/v5092298
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