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Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis
BACKGROUND: We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology. METHODS: The study cohort consisted o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798952/ https://www.ncbi.nlm.nih.gov/pubmed/24008668 http://dx.doi.org/10.1038/bjc.2013.536 |
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author | Warneke, V S Behrens, H-M Haag, J Krüger, S Simon, E Mathiak, M Ebert, M P A Röcken, C |
author_facet | Warneke, V S Behrens, H-M Haag, J Krüger, S Simon, E Mathiak, M Ebert, M P A Röcken, C |
author_sort | Warneke, V S |
collection | PubMed |
description | BACKGROUND: We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology. METHODS: The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17. RESULTS: All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD, E-cadherin, β-catenin, and PSEN2), mucin phenotype (EpEX, EpICD, β-catenin, and ADAM17), T-category (EpEX, E-cadherin, and β-catenin), N-category (EpEX and β-catenin), UICC tumour stage (EpEX, EpICD, β-catenin, and PSEN2), tumour grade (EpEX, EpICD, E-cadherin, β-catenin, and PSEN2), and patients' survival (EpEX, EpICD, and PSEN2). A significant coincidental expression in GC was found for EpEX, EpICD, E-cadherin, β-catenin, PSEN2, and ADAM17. Decreased immunodetection of EpEX in locally advanced GC was not associated with decreased EpCAM mRNA levels. CONCLUSION: All members of the EpCAM signalling pathway are expressed in GC. The expression correlated significantly with each other and with various clinico-pathological patient characteristics, including patients' survival. Thus, the EpCAM signalling pathway is a highly interesting putative therapeutic target in GC. |
format | Online Article Text |
id | pubmed-3798952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37989522014-10-15 Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis Warneke, V S Behrens, H-M Haag, J Krüger, S Simon, E Mathiak, M Ebert, M P A Röcken, C Br J Cancer Molecular Diagnostics BACKGROUND: We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology. METHODS: The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17. RESULTS: All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD, E-cadherin, β-catenin, and PSEN2), mucin phenotype (EpEX, EpICD, β-catenin, and ADAM17), T-category (EpEX, E-cadherin, and β-catenin), N-category (EpEX and β-catenin), UICC tumour stage (EpEX, EpICD, β-catenin, and PSEN2), tumour grade (EpEX, EpICD, E-cadherin, β-catenin, and PSEN2), and patients' survival (EpEX, EpICD, and PSEN2). A significant coincidental expression in GC was found for EpEX, EpICD, E-cadherin, β-catenin, PSEN2, and ADAM17. Decreased immunodetection of EpEX in locally advanced GC was not associated with decreased EpCAM mRNA levels. CONCLUSION: All members of the EpCAM signalling pathway are expressed in GC. The expression correlated significantly with each other and with various clinico-pathological patient characteristics, including patients' survival. Thus, the EpCAM signalling pathway is a highly interesting putative therapeutic target in GC. Nature Publishing Group 2013-10-15 2013-09-05 /pmc/articles/PMC3798952/ /pubmed/24008668 http://dx.doi.org/10.1038/bjc.2013.536 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Molecular Diagnostics Warneke, V S Behrens, H-M Haag, J Krüger, S Simon, E Mathiak, M Ebert, M P A Röcken, C Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title | Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title_full | Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title_fullStr | Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title_full_unstemmed | Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title_short | Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
title_sort | members of the epcam signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798952/ https://www.ncbi.nlm.nih.gov/pubmed/24008668 http://dx.doi.org/10.1038/bjc.2013.536 |
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