New insights into the genetic mechanism of IQ in autism spectrum disorders

Autism spectrum disorders (ASD) comprise a number of underlying sub-types with various symptoms and presumably different genetic causes. One important difference between these sub-phenotypes is IQ. Some forms of ASD such as Asperger’s have relatively intact intelligence while the majority does not....

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Autores principales: Wang, Harold Z., Qin, Hai-De, Guo, Wei, Samuels, Jack, Shugart, Yin Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799005/
https://www.ncbi.nlm.nih.gov/pubmed/24151499
http://dx.doi.org/10.3389/fgene.2013.00195
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author Wang, Harold Z.
Qin, Hai-De
Guo, Wei
Samuels, Jack
Shugart, Yin Yao
author_facet Wang, Harold Z.
Qin, Hai-De
Guo, Wei
Samuels, Jack
Shugart, Yin Yao
author_sort Wang, Harold Z.
collection PubMed
description Autism spectrum disorders (ASD) comprise a number of underlying sub-types with various symptoms and presumably different genetic causes. One important difference between these sub-phenotypes is IQ. Some forms of ASD such as Asperger’s have relatively intact intelligence while the majority does not. In this study, we explored the role of genetic factors that might account for this difference. Using a case–control study based on IQ status in 1657 ASD probands, we analyzed both common and rare variants provided by the Autism Genome Project (AGP) consortium via dbGaP (database of Genotypes and Phenotypes). We identified a set of genes, among them HLA-DRB1 and KIAA0319L, which are strongly associated with IQ within a population of ASD patients.
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spelling pubmed-37990052013-10-22 New insights into the genetic mechanism of IQ in autism spectrum disorders Wang, Harold Z. Qin, Hai-De Guo, Wei Samuels, Jack Shugart, Yin Yao Front Genet Genetics Autism spectrum disorders (ASD) comprise a number of underlying sub-types with various symptoms and presumably different genetic causes. One important difference between these sub-phenotypes is IQ. Some forms of ASD such as Asperger’s have relatively intact intelligence while the majority does not. In this study, we explored the role of genetic factors that might account for this difference. Using a case–control study based on IQ status in 1657 ASD probands, we analyzed both common and rare variants provided by the Autism Genome Project (AGP) consortium via dbGaP (database of Genotypes and Phenotypes). We identified a set of genes, among them HLA-DRB1 and KIAA0319L, which are strongly associated with IQ within a population of ASD patients. Frontiers Media S.A. 2013-10-18 /pmc/articles/PMC3799005/ /pubmed/24151499 http://dx.doi.org/10.3389/fgene.2013.00195 Text en Copyright © Wang, Qin, Guo, Samuels and Shugart. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Harold Z.
Qin, Hai-De
Guo, Wei
Samuels, Jack
Shugart, Yin Yao
New insights into the genetic mechanism of IQ in autism spectrum disorders
title New insights into the genetic mechanism of IQ in autism spectrum disorders
title_full New insights into the genetic mechanism of IQ in autism spectrum disorders
title_fullStr New insights into the genetic mechanism of IQ in autism spectrum disorders
title_full_unstemmed New insights into the genetic mechanism of IQ in autism spectrum disorders
title_short New insights into the genetic mechanism of IQ in autism spectrum disorders
title_sort new insights into the genetic mechanism of iq in autism spectrum disorders
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799005/
https://www.ncbi.nlm.nih.gov/pubmed/24151499
http://dx.doi.org/10.3389/fgene.2013.00195
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