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Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae

Bartonella are hemotropic bacteria responsible for emerging zoonoses. Most Bartonella species appear to share a natural cycle that involves an arthropod transmission, followed by exploitation of a mammalian host in which they cause long-lasting intra-erythrocytic bacteremia. Persistence in erythrocy...

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Autores principales: Liu, MaFeng, Biville, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799009/
https://www.ncbi.nlm.nih.gov/pubmed/24151576
http://dx.doi.org/10.3389/fcimb.2013.00060
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author Liu, MaFeng
Biville, Francis
author_facet Liu, MaFeng
Biville, Francis
author_sort Liu, MaFeng
collection PubMed
description Bartonella are hemotropic bacteria responsible for emerging zoonoses. Most Bartonella species appear to share a natural cycle that involves an arthropod transmission, followed by exploitation of a mammalian host in which they cause long-lasting intra-erythrocytic bacteremia. Persistence in erythrocytes is considered an adaptation to transmission by bloodsucking arthropod vectors and a strategy to obtain heme required for Bartonella growth. Bartonella genomes do not encode for siderophore biosynthesis or a complete iron Fe(3+) transport system. Only genes, sharing strong homology with all components of a Fe(2+) transport system, are present in Bartonella genomes. Also, Bartonella genomes encode for a complete heme transport system. Bartonella must face various environments in their hosts and vectors. In mammals, free heme and iron are rare and oxygen concentration is low. In arthropod vectors, toxic heme levels are found in the gut where oxygen concentration is high. Bartonella genomes encode for 3–5 heme-binding proteins. In Bartonella henselae heme-binding proteins were shown to be involved in heme uptake process, oxidative stress response, and survival inside endothelial cells and in the flea. In this report, we discuss the use of the heme uptake and storage system of B. henselae during its infection cycle. Also, we establish a comparison with the iron and heme uptake systems of Yersinia pestis used during its infection cycle.
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spelling pubmed-37990092013-10-22 Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae Liu, MaFeng Biville, Francis Front Cell Infect Microbiol Microbiology Bartonella are hemotropic bacteria responsible for emerging zoonoses. Most Bartonella species appear to share a natural cycle that involves an arthropod transmission, followed by exploitation of a mammalian host in which they cause long-lasting intra-erythrocytic bacteremia. Persistence in erythrocytes is considered an adaptation to transmission by bloodsucking arthropod vectors and a strategy to obtain heme required for Bartonella growth. Bartonella genomes do not encode for siderophore biosynthesis or a complete iron Fe(3+) transport system. Only genes, sharing strong homology with all components of a Fe(2+) transport system, are present in Bartonella genomes. Also, Bartonella genomes encode for a complete heme transport system. Bartonella must face various environments in their hosts and vectors. In mammals, free heme and iron are rare and oxygen concentration is low. In arthropod vectors, toxic heme levels are found in the gut where oxygen concentration is high. Bartonella genomes encode for 3–5 heme-binding proteins. In Bartonella henselae heme-binding proteins were shown to be involved in heme uptake process, oxidative stress response, and survival inside endothelial cells and in the flea. In this report, we discuss the use of the heme uptake and storage system of B. henselae during its infection cycle. Also, we establish a comparison with the iron and heme uptake systems of Yersinia pestis used during its infection cycle. Frontiers Media S.A. 2013-10-18 /pmc/articles/PMC3799009/ /pubmed/24151576 http://dx.doi.org/10.3389/fcimb.2013.00060 Text en Copyright © 2013 Liu and Biville. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Liu, MaFeng
Biville, Francis
Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title_full Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title_fullStr Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title_full_unstemmed Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title_short Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae
title_sort managing iron supply during the infection cycle of a flea borne pathogen, bartonella henselae
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799009/
https://www.ncbi.nlm.nih.gov/pubmed/24151576
http://dx.doi.org/10.3389/fcimb.2013.00060
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