Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain

Summary: We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the...

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Autores principales: Ryder, Edward, Wong, Kim, Gleeson, Diane, Keane, Thomas M, Sethi, Debarati, Vyas, Sapna, Wardle-Jones, Hannah, Bussell, James N, Houghton, Richard, Salisbury, Jennifer, Harvey, Nina, Adams, David J, Ramirez-Solis, Ramiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Technology Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799019/
https://www.ncbi.nlm.nih.gov/pubmed/23620107
http://dx.doi.org/10.1002/dvg.22398
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author Ryder, Edward
Wong, Kim
Gleeson, Diane
Keane, Thomas M
Sethi, Debarati
Vyas, Sapna
Wardle-Jones, Hannah
Bussell, James N
Houghton, Richard
Salisbury, Jennifer
Harvey, Nina
Adams, David J
Ramirez-Solis, Ramiro
author_facet Ryder, Edward
Wong, Kim
Gleeson, Diane
Keane, Thomas M
Sethi, Debarati
Vyas, Sapna
Wardle-Jones, Hannah
Bussell, James N
Houghton, Richard
Salisbury, Jennifer
Harvey, Nina
Adams, David J
Ramirez-Solis, Ramiro
author_sort Ryder, Edward
collection PubMed
description Summary: We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528.
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spelling pubmed-37990192013-10-23 Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain Ryder, Edward Wong, Kim Gleeson, Diane Keane, Thomas M Sethi, Debarati Vyas, Sapna Wardle-Jones, Hannah Bussell, James N Houghton, Richard Salisbury, Jennifer Harvey, Nina Adams, David J Ramirez-Solis, Ramiro Genesis Technology Reports Summary: We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. Blackwell Publishing Ltd 2013-07 2013-04-26 /pmc/articles/PMC3799019/ /pubmed/23620107 http://dx.doi.org/10.1002/dvg.22398 Text en Copyright © 2013 Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Technology Reports
Ryder, Edward
Wong, Kim
Gleeson, Diane
Keane, Thomas M
Sethi, Debarati
Vyas, Sapna
Wardle-Jones, Hannah
Bussell, James N
Houghton, Richard
Salisbury, Jennifer
Harvey, Nina
Adams, David J
Ramirez-Solis, Ramiro
Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title_full Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title_fullStr Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title_full_unstemmed Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title_short Genomic Analysis of a Novel Spontaneous Albino C57BL/6N Mouse Strain
title_sort genomic analysis of a novel spontaneous albino c57bl/6n mouse strain
topic Technology Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799019/
https://www.ncbi.nlm.nih.gov/pubmed/23620107
http://dx.doi.org/10.1002/dvg.22398
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