Reduction in serum clusterin is a potential therapeutic biomarker in patients with castration-resistant prostate cancer treated with custirsen

Elevated levels of clusterin (CLU), a stress-induced and secreted cytoprotective chaperone, are associated with advanced tumor stage, metastasis, treatment resistance, and adverse outcome in several cancers. Custirsen, a second-generation antisense oligonucleotide, inhibits CLU production in tumor c...

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Detalles Bibliográficos
Autores principales: Blumenstein, Brent, Saad, Fred, Hotte, Sebastien, Chi, Kim N, Eigl, Bernhard, Gleave, Martin, Jacobs, Cindy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799281/
https://www.ncbi.nlm.nih.gov/pubmed/24156019
http://dx.doi.org/10.1002/cam4.93

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799281/
https://www.ncbi.nlm.nih.gov/pubmed/24156019
http://dx.doi.org/10.1002/cam4.93

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