Cargando…
Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics
Internal cavities are a common feature of many proteins, often having profound effects on the dynamics of their interactions with substrate and binding partners. RB69 DNA polymerase (pol) has a hydrophobic cavity right below the nucleotide binding pocket at the tip of highly conserved L415 side chai...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799440/ https://www.ncbi.nlm.nih.gov/pubmed/23921641 http://dx.doi.org/10.1093/nar/gkt674 |