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Eradication of HIV and Cure of AIDS, Now and How?
Recent studies have highlighted the importance of eradication of human immunodeficiency virus (HIV) and cure of acquired immunodeficiency syndrome (AIDS). However, a pivotal point that the patient immunity controls HIV reactivation after highly active anti-retroviral therapy [HAART or combination an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799464/ https://www.ncbi.nlm.nih.gov/pubmed/24151495 http://dx.doi.org/10.3389/fimmu.2013.00337 |
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author | Zhang, Jielin Crumpacker, Clyde |
author_facet | Zhang, Jielin Crumpacker, Clyde |
author_sort | Zhang, Jielin |
collection | PubMed |
description | Recent studies have highlighted the importance of eradication of human immunodeficiency virus (HIV) and cure of acquired immunodeficiency syndrome (AIDS). However, a pivotal point that the patient immunity controls HIV reactivation after highly active anti-retroviral therapy [HAART or combination anti-retroviral therapy (cART)] remains less well addressed. In spite of the fact that both innate and adaptive immunities are indispensable and numerous cells participate in the anti-HIV immunity, memory CD4 T-cells are indisputably the key cells organizing all immune actions against HIV while being the targets of HIV. Here we present a view and multidisciplinary approaches to HIV/AIDS eradication and cure. We aim at memory CD4 T-cells, utilizing the stem cell properties of these cells to reprogram an anti-HIV memory repertoire to eliminate the viral reservoir, toward achieving an AIDS-free world. |
format | Online Article Text |
id | pubmed-3799464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37994642013-10-22 Eradication of HIV and Cure of AIDS, Now and How? Zhang, Jielin Crumpacker, Clyde Front Immunol Immunology Recent studies have highlighted the importance of eradication of human immunodeficiency virus (HIV) and cure of acquired immunodeficiency syndrome (AIDS). However, a pivotal point that the patient immunity controls HIV reactivation after highly active anti-retroviral therapy [HAART or combination anti-retroviral therapy (cART)] remains less well addressed. In spite of the fact that both innate and adaptive immunities are indispensable and numerous cells participate in the anti-HIV immunity, memory CD4 T-cells are indisputably the key cells organizing all immune actions against HIV while being the targets of HIV. Here we present a view and multidisciplinary approaches to HIV/AIDS eradication and cure. We aim at memory CD4 T-cells, utilizing the stem cell properties of these cells to reprogram an anti-HIV memory repertoire to eliminate the viral reservoir, toward achieving an AIDS-free world. Frontiers Media S.A. 2013-10-18 /pmc/articles/PMC3799464/ /pubmed/24151495 http://dx.doi.org/10.3389/fimmu.2013.00337 Text en Copyright © 2013 Zhang and Crumpacker. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Jielin Crumpacker, Clyde Eradication of HIV and Cure of AIDS, Now and How? |
title | Eradication of HIV and Cure of AIDS, Now and How? |
title_full | Eradication of HIV and Cure of AIDS, Now and How? |
title_fullStr | Eradication of HIV and Cure of AIDS, Now and How? |
title_full_unstemmed | Eradication of HIV and Cure of AIDS, Now and How? |
title_short | Eradication of HIV and Cure of AIDS, Now and How? |
title_sort | eradication of hiv and cure of aids, now and how? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799464/ https://www.ncbi.nlm.nih.gov/pubmed/24151495 http://dx.doi.org/10.3389/fimmu.2013.00337 |
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