Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence

Megakaryoblastic leukaemia 1 and 2 (MKL1/2) are coactivators of the transcription factor serum response factor (SRF). Here, we provide evidence that depletion of MKL1 and 2 abolishes hepatocellular carcinoma (HCC) xenograft growth. Loss of the tumour suppressor deleted in liver cancer 1 (DLC1) and t...

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Detalles Bibliográficos
Autores principales: Hampl, Veronika, Martin, Claudia, Aigner, Achim, Hoebel, Sabrina, Singer, Stephan, Frank, Natalie, Sarikas, Antonio, Ebert, Oliver, Prywes, Ron, Gudermann, Thomas, Muehlich, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799492/
https://www.ncbi.nlm.nih.gov/pubmed/23853104
http://dx.doi.org/10.1002/emmm.201202406

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