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Antimicrobial peptides and gut microbiota in homeostasis and pathology

We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while not initiating ongoing inflammatory processes and risking collateral damage to the host. Major players in this scenario are antimicrobial pept...

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Autores principales: Ostaff, Maureen J, Stange, Eduard Friedrich, Wehkamp, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799574/
https://www.ncbi.nlm.nih.gov/pubmed/24039130
http://dx.doi.org/10.1002/emmm.201201773
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author Ostaff, Maureen J
Stange, Eduard Friedrich
Wehkamp, Jan
author_facet Ostaff, Maureen J
Stange, Eduard Friedrich
Wehkamp, Jan
author_sort Ostaff, Maureen J
collection PubMed
description We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while not initiating ongoing inflammatory processes and risking collateral damage to the host. Major players in this scenario are antimicrobial peptides (AMPs). Such broad-spectrum innate antibiotics are in part produced by specialized cells but also widely sourced from all epithelia as well as circulating inflammatory cells. AMPs belong to an ancient defense system found in all organisms and participated in a preservative co-evolution with a complex microbiome. Particularly interesting interactions between host barrier and microbiota can be found in the gut. The intestinal cell lining not only has to maintain a tightly regulated homeostasis during its high-throughput regeneration, but also a balanced relationship towards an extreme number of mutualistic or commensal inhabitants. Recent research suggests that advancing our understanding of the circumstances of such balanced and sometimes imbalanced interactions between gut microbiota and host AMPs should have therapeutic implications for different intestinal disorders.
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spelling pubmed-37995742013-10-23 Antimicrobial peptides and gut microbiota in homeostasis and pathology Ostaff, Maureen J Stange, Eduard Friedrich Wehkamp, Jan EMBO Mol Med Review We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while not initiating ongoing inflammatory processes and risking collateral damage to the host. Major players in this scenario are antimicrobial peptides (AMPs). Such broad-spectrum innate antibiotics are in part produced by specialized cells but also widely sourced from all epithelia as well as circulating inflammatory cells. AMPs belong to an ancient defense system found in all organisms and participated in a preservative co-evolution with a complex microbiome. Particularly interesting interactions between host barrier and microbiota can be found in the gut. The intestinal cell lining not only has to maintain a tightly regulated homeostasis during its high-throughput regeneration, but also a balanced relationship towards an extreme number of mutualistic or commensal inhabitants. Recent research suggests that advancing our understanding of the circumstances of such balanced and sometimes imbalanced interactions between gut microbiota and host AMPs should have therapeutic implications for different intestinal disorders. Blackwell Publishing Ltd 2013-10 2013-08-23 /pmc/articles/PMC3799574/ /pubmed/24039130 http://dx.doi.org/10.1002/emmm.201201773 Text en © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review
Ostaff, Maureen J
Stange, Eduard Friedrich
Wehkamp, Jan
Antimicrobial peptides and gut microbiota in homeostasis and pathology
title Antimicrobial peptides and gut microbiota in homeostasis and pathology
title_full Antimicrobial peptides and gut microbiota in homeostasis and pathology
title_fullStr Antimicrobial peptides and gut microbiota in homeostasis and pathology
title_full_unstemmed Antimicrobial peptides and gut microbiota in homeostasis and pathology
title_short Antimicrobial peptides and gut microbiota in homeostasis and pathology
title_sort antimicrobial peptides and gut microbiota in homeostasis and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799574/
https://www.ncbi.nlm.nih.gov/pubmed/24039130
http://dx.doi.org/10.1002/emmm.201201773
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