Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

The deletion of Phe508 (ΔF508) in the first nucleotide binding domain (NBD1) of CFTR is the most common mutation associated with cystic fibrosis. The ΔF508-CFTR mutant is recognized as improperly folded and targeted for proteasomal degradation. Based on molecular dynamics simulation results, we hypo...

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Detalles Bibliográficos
Autores principales: Odolczyk, Norbert, Fritsch, Janine, Norez, Caroline, Servel, Nathalie, da Cunha, Melanie Faria, Bitam, Sara, Kupniewska, Anna, Wiszniewski, Ludovic, Colas, Julien, Tarnowski, Krzysztof, Tondelier, Danielle, Roldan, Ariel, Saussereau, Emilie L, Melin-Heschel, Patricia, Wieczorek, Grzegorz, Lukacs, Gergely L, Dadlez, Michal, Faure, Grazyna, Herrmann, Harald, Ollero, Mario, Becq, Frédéric, Zielenkiewicz, Piotr, Edelman, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799575/
https://www.ncbi.nlm.nih.gov/pubmed/23982976
http://dx.doi.org/10.1002/emmm.201302699

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