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Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy
Background Pulmonary arterial hypertension carries a high risk of mortality in pregnancy. Recent advances in treatment may improve disease course and allow for successful management of the pregnancy. Case Report We present the case of a 20-year-old gravida 1, para 0 with diagnosis of severe primary...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical Publishers
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799704/ https://www.ncbi.nlm.nih.gov/pubmed/24147238 http://dx.doi.org/10.1055/s-0033-1338169 |
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author | Timofeev, Julia Ruiz, George Fries, Melissa Driggers, Rita W. |
author_facet | Timofeev, Julia Ruiz, George Fries, Melissa Driggers, Rita W. |
author_sort | Timofeev, Julia |
collection | PubMed |
description | Background Pulmonary arterial hypertension carries a high risk of mortality in pregnancy. Recent advances in treatment may improve disease course and allow for successful management of the pregnancy. Case Report We present the case of a 20-year-old gravida 1, para 0 with diagnosis of severe primary pulmonary hypertension. The patient was managed with epoprostenol (prostacyclin) infusion via an indwelling catheter, which was initiated at 23 weeks' gestation. The dose was adjusted to the patient's symptoms and a successful vaginal delivery was achieved at 36 weeks' gestation. Although maternal postpartum course was uncomplicated, unexplained neonatal demise occurred at 11 days of life. Conclusion Successful management of pulmonary hypertension in pregnancy can be accomplished with a multidisciplinary approach and intensive therapy. Long-term effects of epoprostenol on fetal or neonatal well-being are unknown. |
format | Online Article Text |
id | pubmed-3799704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Thieme Medical Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-37997042013-10-21 Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy Timofeev, Julia Ruiz, George Fries, Melissa Driggers, Rita W. AJP Rep Article Background Pulmonary arterial hypertension carries a high risk of mortality in pregnancy. Recent advances in treatment may improve disease course and allow for successful management of the pregnancy. Case Report We present the case of a 20-year-old gravida 1, para 0 with diagnosis of severe primary pulmonary hypertension. The patient was managed with epoprostenol (prostacyclin) infusion via an indwelling catheter, which was initiated at 23 weeks' gestation. The dose was adjusted to the patient's symptoms and a successful vaginal delivery was achieved at 36 weeks' gestation. Although maternal postpartum course was uncomplicated, unexplained neonatal demise occurred at 11 days of life. Conclusion Successful management of pulmonary hypertension in pregnancy can be accomplished with a multidisciplinary approach and intensive therapy. Long-term effects of epoprostenol on fetal or neonatal well-being are unknown. Thieme Medical Publishers 2013-03-18 2013-10 /pmc/articles/PMC3799704/ /pubmed/24147238 http://dx.doi.org/10.1055/s-0033-1338169 Text en © Thieme Medical Publishers |
spellingShingle | Article Timofeev, Julia Ruiz, George Fries, Melissa Driggers, Rita W. Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title | Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title_full | Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title_fullStr | Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title_full_unstemmed | Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title_short | Intravenous Epoprostenol for Management of Pulmonary Arterial Hypertension during Pregnancy |
title_sort | intravenous epoprostenol for management of pulmonary arterial hypertension during pregnancy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799704/ https://www.ncbi.nlm.nih.gov/pubmed/24147238 http://dx.doi.org/10.1055/s-0033-1338169 |
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