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Using Genetic Prediction from Known Complex Disease Loci to Guide the Design of Next-Generation Sequencing Experiments

A central focus of complex disease genetics after genome-wide association studies (GWAS) is to identify low frequency and rare risk variants, which may account for an important fraction of disease heritability unexplained by GWAS. A profusion of studies using next-generation sequencing are seeking s...

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Detalles Bibliográficos
Autores principales:	Jostins, Luke, Levine, Adam P., Barrett, Jeffrey C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799779/ https://www.ncbi.nlm.nih.gov/pubmed/24204614 http://dx.doi.org/10.1371/journal.pone.0076328

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