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Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes

STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as in inflammation. Histone acetylation-mediated...

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Detalles Bibliográficos
Autores principales:	Garrigan, Erin, Belkin, Nicole S., Alexander, John J., Han, Zhao, Seydel, Federica, Carter, Jamal, Atkinson, Mark, Wasserfall, Clive, Clare-Salzler, Michael J., Amick, Matthew A., Litherland, Sally A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799903/ https://www.ncbi.nlm.nih.gov/pubmed/24204704 http://dx.doi.org/10.1371/journal.pone.0076919

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