Cargando…

Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis

PURPOSE: The objective of the present study was to conduct a systematic review and meta-analysis of published literature investigating the survivin expression and its effects on bladder cancer prognosis. MATERIALS AND METHODS: We carefully searched online Pubmed, Cochrane Library and SCOPUS database...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeon, Chanhoo, Kim, Myong, Kwak, Cheol, Kim, Hyeon Hoe, Ku, Ja Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799942/
https://www.ncbi.nlm.nih.gov/pubmed/24204662
http://dx.doi.org/10.1371/journal.pone.0076719
_version_ 1782287934895947776
author Jeon, Chanhoo
Kim, Myong
Kwak, Cheol
Kim, Hyeon Hoe
Ku, Ja Hyeon
author_facet Jeon, Chanhoo
Kim, Myong
Kwak, Cheol
Kim, Hyeon Hoe
Ku, Ja Hyeon
author_sort Jeon, Chanhoo
collection PubMed
description PURPOSE: The objective of the present study was to conduct a systematic review and meta-analysis of published literature investigating the survivin expression and its effects on bladder cancer prognosis. MATERIALS AND METHODS: We carefully searched online Pubmed, Cochrane Library and SCOPUS database from August 1997 to May 2013. RESULTS: A total of 14 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 2,165 patients with a median number of 155 patients per study (range: 17–726). Of the 14 studies, nine evaluated immunohistochemistry in formalin-fixed paraffin-embedded tissue blocks. In non-muscle invasive bladder tumor, the pooled hazard ratio (HR) was statistically significant for recurrence-free survival (pooled HR, 1.81; 95% confidence interval [CI], 1.30–2.52), progression-free survival (pooled HR, 2.12; 95% CI, 1.60–2.82), cancer-specific survival (pooled HR, 2.01; 95% CI, 1.32–3.06), and overall survival (pooled HR, 1.53; 95% CI, 1.02–2.29). The overall HRs by survivin status were robust across advanced stages. When only adjusted survival data were included, statistically significant differences were identified for all survival subgroup analyses. There was no between-study heterogeneity in the effect of survivin status on the majority of meta-analyses. There was no clear evidence of publication bias in this meta-analysis. CONCLUSIONS: Survivin expression indicates worse prognosis in patients with bladder cancer but the results should be interpreted with caution. It is necessary that better-designed studies with standardized assays need to provide a better conclusion about the relationship between survivin expression and the outcome of patients with bladder cancer.
format Online
Article
Text
id pubmed-3799942
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-37999422013-11-07 Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis Jeon, Chanhoo Kim, Myong Kwak, Cheol Kim, Hyeon Hoe Ku, Ja Hyeon PLoS One Research Article PURPOSE: The objective of the present study was to conduct a systematic review and meta-analysis of published literature investigating the survivin expression and its effects on bladder cancer prognosis. MATERIALS AND METHODS: We carefully searched online Pubmed, Cochrane Library and SCOPUS database from August 1997 to May 2013. RESULTS: A total of 14 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 2,165 patients with a median number of 155 patients per study (range: 17–726). Of the 14 studies, nine evaluated immunohistochemistry in formalin-fixed paraffin-embedded tissue blocks. In non-muscle invasive bladder tumor, the pooled hazard ratio (HR) was statistically significant for recurrence-free survival (pooled HR, 1.81; 95% confidence interval [CI], 1.30–2.52), progression-free survival (pooled HR, 2.12; 95% CI, 1.60–2.82), cancer-specific survival (pooled HR, 2.01; 95% CI, 1.32–3.06), and overall survival (pooled HR, 1.53; 95% CI, 1.02–2.29). The overall HRs by survivin status were robust across advanced stages. When only adjusted survival data were included, statistically significant differences were identified for all survival subgroup analyses. There was no between-study heterogeneity in the effect of survivin status on the majority of meta-analyses. There was no clear evidence of publication bias in this meta-analysis. CONCLUSIONS: Survivin expression indicates worse prognosis in patients with bladder cancer but the results should be interpreted with caution. It is necessary that better-designed studies with standardized assays need to provide a better conclusion about the relationship between survivin expression and the outcome of patients with bladder cancer. Public Library of Science 2013-10-18 /pmc/articles/PMC3799942/ /pubmed/24204662 http://dx.doi.org/10.1371/journal.pone.0076719 Text en © 2013 Jeon et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jeon, Chanhoo
Kim, Myong
Kwak, Cheol
Kim, Hyeon Hoe
Ku, Ja Hyeon
Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title_full Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title_fullStr Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title_full_unstemmed Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title_short Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis
title_sort prognostic role of survivin in bladder cancer: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799942/
https://www.ncbi.nlm.nih.gov/pubmed/24204662
http://dx.doi.org/10.1371/journal.pone.0076719
work_keys_str_mv AT jeonchanhoo prognosticroleofsurvivininbladdercancerasystematicreviewandmetaanalysis
AT kimmyong prognosticroleofsurvivininbladdercancerasystematicreviewandmetaanalysis
AT kwakcheol prognosticroleofsurvivininbladdercancerasystematicreviewandmetaanalysis
AT kimhyeonhoe prognosticroleofsurvivininbladdercancerasystematicreviewandmetaanalysis
AT kujahyeon prognosticroleofsurvivininbladdercancerasystematicreviewandmetaanalysis