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Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States
Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800008/ https://www.ncbi.nlm.nih.gov/pubmed/24205232 http://dx.doi.org/10.1371/journal.pone.0078434 |
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author | Chikahisa, Sachiko Kodama, Tohru Soya, Atsushi Sagawa, Yohei Ishimaru, Yuji Séi, Hiroyoshi Nishino, Seiji |
author_facet | Chikahisa, Sachiko Kodama, Tohru Soya, Atsushi Sagawa, Yohei Ishimaru, Yuji Séi, Hiroyoshi Nishino, Seiji |
author_sort | Chikahisa, Sachiko |
collection | PubMed |
description | Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this study, we examined potential involvement of brain mast cells in sleep/wake regulations, focusing especially on the histaminergic system, using mast cell deficient (W/W(v)) mice. No significant difference was found in the basal amount of sleep/wake between W/W(v) mice and their wild-type littermates (WT), although W/W(v) mice showed increased EEG delta power and attenuated rebound response after sleep deprivation. Intracerebroventricular injection of compound 48/80, a histamine releaser from mast cells, significantly increased histamine levels in the ventricular region and enhanced wakefulness in WT mice, while it had no effect in W/W(v) mice. Injection of H1 antagonists (triprolidine and mepyramine) significantly increased the amounts of slow-wave sleep in WT mice, but not in W/W(v) mice. Most strikingly, the food-seeking behavior observed in WT mice during food deprivation was completely abolished in W/W(v) mice. W/W(v) mice also exhibited higher anxiety and depression levels compared to WT mice. Our findings suggest that histamine released from brain mast cells is wake-promoting, and emphasizes the physiological and pharmacological importance of brain mast cells in the regulation of sleep and fundamental neurobehavior. |
format | Online Article Text |
id | pubmed-3800008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38000082013-11-07 Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States Chikahisa, Sachiko Kodama, Tohru Soya, Atsushi Sagawa, Yohei Ishimaru, Yuji Séi, Hiroyoshi Nishino, Seiji PLoS One Research Article Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this study, we examined potential involvement of brain mast cells in sleep/wake regulations, focusing especially on the histaminergic system, using mast cell deficient (W/W(v)) mice. No significant difference was found in the basal amount of sleep/wake between W/W(v) mice and their wild-type littermates (WT), although W/W(v) mice showed increased EEG delta power and attenuated rebound response after sleep deprivation. Intracerebroventricular injection of compound 48/80, a histamine releaser from mast cells, significantly increased histamine levels in the ventricular region and enhanced wakefulness in WT mice, while it had no effect in W/W(v) mice. Injection of H1 antagonists (triprolidine and mepyramine) significantly increased the amounts of slow-wave sleep in WT mice, but not in W/W(v) mice. Most strikingly, the food-seeking behavior observed in WT mice during food deprivation was completely abolished in W/W(v) mice. W/W(v) mice also exhibited higher anxiety and depression levels compared to WT mice. Our findings suggest that histamine released from brain mast cells is wake-promoting, and emphasizes the physiological and pharmacological importance of brain mast cells in the regulation of sleep and fundamental neurobehavior. Public Library of Science 2013-10-18 /pmc/articles/PMC3800008/ /pubmed/24205232 http://dx.doi.org/10.1371/journal.pone.0078434 Text en © 2013 Chikahisa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chikahisa, Sachiko Kodama, Tohru Soya, Atsushi Sagawa, Yohei Ishimaru, Yuji Séi, Hiroyoshi Nishino, Seiji Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title | Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title_full | Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title_fullStr | Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title_full_unstemmed | Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title_short | Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States |
title_sort | histamine from brain resident mast cells promotes wakefulness and modulates behavioral states |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800008/ https://www.ncbi.nlm.nih.gov/pubmed/24205232 http://dx.doi.org/10.1371/journal.pone.0078434 |
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