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Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator

PURPOSE OF THE STUDY: The indigenous design and technology development for processing large scale zirconium molybdate-Mo-99 (ZrMo-99) Geltech generator was successfully commissioned in Board of Radiation and Isotope Technology (BRIT), India, in 2006. The generator production facility comprises of fo...

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Autores principales: Sarkar, Sishir Kumar, Kothalkar, Chetan, Naskar, Prabhakar, Joshi, Sangeeta, Saraswathy, Padmanabhan, Dey, Arun Chandra, Vispute, Gunvant Leeladhar, Murhekar, Vishwas Vinayak, Pilkhwal, Neelam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800314/
https://www.ncbi.nlm.nih.gov/pubmed/24163509
http://dx.doi.org/10.4103/0972-3919.118226
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author Sarkar, Sishir Kumar
Kothalkar, Chetan
Naskar, Prabhakar
Joshi, Sangeeta
Saraswathy, Padmanabhan
Dey, Arun Chandra
Vispute, Gunvant Leeladhar
Murhekar, Vishwas Vinayak
Pilkhwal, Neelam
author_facet Sarkar, Sishir Kumar
Kothalkar, Chetan
Naskar, Prabhakar
Joshi, Sangeeta
Saraswathy, Padmanabhan
Dey, Arun Chandra
Vispute, Gunvant Leeladhar
Murhekar, Vishwas Vinayak
Pilkhwal, Neelam
author_sort Sarkar, Sishir Kumar
collection PubMed
description PURPOSE OF THE STUDY: The indigenous design and technology development for processing large scale zirconium molybdate-Mo-99 (ZrMo-99) Geltech generator was successfully commissioned in Board of Radiation and Isotope Technology (BRIT), India, in 2006. The generator production facility comprises of four shielded plant facilities equipped with tongs and special process gadgets amenable for remote operations for radiochemical processing of ZrMo-99 gel. RESULTS: Over 2800 Geltech generators have been processed and supplied to user hospitals during the period 2006-2013. Geltech generator supplied by BRIT was initially not sterile. Simple elution of Tc-99m is performed by a sterile evacuated vial with sterile and pyrogen free 0.9% NaCl solution to obtain sodium (Tc-99m) pertechnetate solution. A special type online 0.22 μm membrane filter has been identified and adapted in Geltech generator. CONCLUSIONS: The online filtration of Tc-99m from Geltech generator; thus, provided sterile Tc-99m sodium pertechnetate solution. Generators assembled with modified filter assembly were supplied to local hospital in Mumbai Radiation Medicine Centre (RMC) and S.G.S. Medical College and KEM Hospital) and excellent performances were reported by users.
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spelling pubmed-38003142013-10-25 Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator Sarkar, Sishir Kumar Kothalkar, Chetan Naskar, Prabhakar Joshi, Sangeeta Saraswathy, Padmanabhan Dey, Arun Chandra Vispute, Gunvant Leeladhar Murhekar, Vishwas Vinayak Pilkhwal, Neelam Indian J Nucl Med Original Article PURPOSE OF THE STUDY: The indigenous design and technology development for processing large scale zirconium molybdate-Mo-99 (ZrMo-99) Geltech generator was successfully commissioned in Board of Radiation and Isotope Technology (BRIT), India, in 2006. The generator production facility comprises of four shielded plant facilities equipped with tongs and special process gadgets amenable for remote operations for radiochemical processing of ZrMo-99 gel. RESULTS: Over 2800 Geltech generators have been processed and supplied to user hospitals during the period 2006-2013. Geltech generator supplied by BRIT was initially not sterile. Simple elution of Tc-99m is performed by a sterile evacuated vial with sterile and pyrogen free 0.9% NaCl solution to obtain sodium (Tc-99m) pertechnetate solution. A special type online 0.22 μm membrane filter has been identified and adapted in Geltech generator. CONCLUSIONS: The online filtration of Tc-99m from Geltech generator; thus, provided sterile Tc-99m sodium pertechnetate solution. Generators assembled with modified filter assembly were supplied to local hospital in Mumbai Radiation Medicine Centre (RMC) and S.G.S. Medical College and KEM Hospital) and excellent performances were reported by users. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3800314/ /pubmed/24163509 http://dx.doi.org/10.4103/0972-3919.118226 Text en Copyright: © Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sarkar, Sishir Kumar
Kothalkar, Chetan
Naskar, Prabhakar
Joshi, Sangeeta
Saraswathy, Padmanabhan
Dey, Arun Chandra
Vispute, Gunvant Leeladhar
Murhekar, Vishwas Vinayak
Pilkhwal, Neelam
Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title_full Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title_fullStr Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title_full_unstemmed Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title_short Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator
title_sort indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-tc-99m solution from geltech generator
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800314/
https://www.ncbi.nlm.nih.gov/pubmed/24163509
http://dx.doi.org/10.4103/0972-3919.118226
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