Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by ele...

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Detalles Bibliográficos
Autores principales: Alswah, Mohamed, Ghiaty, Adel, El-Morsy, Ahmed, El-Gamal, Kamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800542/
https://www.ncbi.nlm.nih.gov/pubmed/24198971
http://dx.doi.org/10.1155/2013/587054
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author Alswah, Mohamed
Ghiaty, Adel
El-Morsy, Ahmed
El-Gamal, Kamal
author_facet Alswah, Mohamed
Ghiaty, Adel
El-Morsy, Ahmed
El-Gamal, Kamal
author_sort Alswah, Mohamed
collection PubMed
description 2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.
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spelling pubmed-38005422013-11-06 Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents Alswah, Mohamed Ghiaty, Adel El-Morsy, Ahmed El-Gamal, Kamal ISRN Org Chem Research Article 2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities. Hindawi Publishing Corporation 2013-09-12 /pmc/articles/PMC3800542/ /pubmed/24198971 http://dx.doi.org/10.1155/2013/587054 Text en Copyright © 2013 Mohamed Alswah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alswah, Mohamed
Ghiaty, Adel
El-Morsy, Ahmed
El-Gamal, Kamal
Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title_full Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title_fullStr Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title_full_unstemmed Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title_short Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
title_sort synthesis and biological evaluation of some [1,2,4]triazolo[4,3-a]quinoxaline derivatives as novel anticonvulsant agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800542/
https://www.ncbi.nlm.nih.gov/pubmed/24198971
http://dx.doi.org/10.1155/2013/587054
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