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Insulin and the Lung: Connecting Asthma and Metabolic Syndrome

Obesity, metabolic syndrome, and asthma are all rapidly increasing globally. Substantial emerging evidence suggests that these three conditions are epidemiologically and mechanistically linked. Since the link between obesity and asthma appears to extend beyond mechanical pulmonary disadvantage, mole...

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Detalles Bibliográficos
Autores principales: Singh, Suchita, Prakash, Y. S., Linneberg, Allan, Agrawal, Anurag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800560/
https://www.ncbi.nlm.nih.gov/pubmed/24204385
http://dx.doi.org/10.1155/2013/627384
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author Singh, Suchita
Prakash, Y. S.
Linneberg, Allan
Agrawal, Anurag
author_facet Singh, Suchita
Prakash, Y. S.
Linneberg, Allan
Agrawal, Anurag
author_sort Singh, Suchita
collection PubMed
description Obesity, metabolic syndrome, and asthma are all rapidly increasing globally. Substantial emerging evidence suggests that these three conditions are epidemiologically and mechanistically linked. Since the link between obesity and asthma appears to extend beyond mechanical pulmonary disadvantage, molecular understanding is necessary. Insulin resistance is a strong, independent risk factor for asthma development, but it is unknown whether a direct effect of insulin on the lung is involved. This review summarizes current knowledge regarding the effect of insulin on cellular components of the lung and highlights the molecular consequences of insulin-related metabolic signaling cascades that could adversely affect lung structure and function. Examples include airway smooth muscle proliferation and contractility and regulatory signaling networks that are associated with asthma. These aspects of insulin signaling provide mechanistic insight into the clinical evidence for the links between obesity, metabolic syndrome, and airway diseases, setting the stage for novel therapeutic avenues targeting these conditions.
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spelling pubmed-38005602013-11-07 Insulin and the Lung: Connecting Asthma and Metabolic Syndrome Singh, Suchita Prakash, Y. S. Linneberg, Allan Agrawal, Anurag J Allergy (Cairo) Review Article Obesity, metabolic syndrome, and asthma are all rapidly increasing globally. Substantial emerging evidence suggests that these three conditions are epidemiologically and mechanistically linked. Since the link between obesity and asthma appears to extend beyond mechanical pulmonary disadvantage, molecular understanding is necessary. Insulin resistance is a strong, independent risk factor for asthma development, but it is unknown whether a direct effect of insulin on the lung is involved. This review summarizes current knowledge regarding the effect of insulin on cellular components of the lung and highlights the molecular consequences of insulin-related metabolic signaling cascades that could adversely affect lung structure and function. Examples include airway smooth muscle proliferation and contractility and regulatory signaling networks that are associated with asthma. These aspects of insulin signaling provide mechanistic insight into the clinical evidence for the links between obesity, metabolic syndrome, and airway diseases, setting the stage for novel therapeutic avenues targeting these conditions. Hindawi Publishing Corporation 2013 2013-09-24 /pmc/articles/PMC3800560/ /pubmed/24204385 http://dx.doi.org/10.1155/2013/627384 Text en Copyright © 2013 Suchita Singh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Suchita
Prakash, Y. S.
Linneberg, Allan
Agrawal, Anurag
Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title_full Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title_fullStr Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title_full_unstemmed Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title_short Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
title_sort insulin and the lung: connecting asthma and metabolic syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800560/
https://www.ncbi.nlm.nih.gov/pubmed/24204385
http://dx.doi.org/10.1155/2013/627384
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