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Risk of Cancer in Diabetes: The Effect of Metformin

Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer re...

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Autores principales: Malek, Mojtaba, Aghili, Rokhsareh, Emami, Zahra, Khamseh, Mohammad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800579/
https://www.ncbi.nlm.nih.gov/pubmed/24224094
http://dx.doi.org/10.1155/2013/636927
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author Malek, Mojtaba
Aghili, Rokhsareh
Emami, Zahra
Khamseh, Mohammad E.
author_facet Malek, Mojtaba
Aghili, Rokhsareh
Emami, Zahra
Khamseh, Mohammad E.
author_sort Malek, Mojtaba
collection PubMed
description Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer response to cancer treatment, and excess mortality related to diabetes are among the most important explanations. Although diabetes appear to be a risk factor for cancer and is associated with the mortality risk in cancer patients, several factors such as diabetes duration, multiple drug therapy, and the presence of diabetes comorbidities make the assessment of the effect of diabetes treatment on cancer risk and mortality difficult. Metformin is the drug of choice for the treatment of type 2 diabetes. The available evidence from basic science, clinical, and population-based research supports the anticancer effect of metformin. However, randomized controlled clinical trials do not provide enough evidence for a strong protective effect of metformin on cancer incidence or mortality. One of the most important limitations of these trials is the short duration of the followup. Further long-term randomized controlled clinical trials specifically designed to determine metformin effect on cancer risk are needed to provide the best answer to this challenge.
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spelling pubmed-38005792013-11-10 Risk of Cancer in Diabetes: The Effect of Metformin Malek, Mojtaba Aghili, Rokhsareh Emami, Zahra Khamseh, Mohammad E. ISRN Endocrinol Review Article Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer response to cancer treatment, and excess mortality related to diabetes are among the most important explanations. Although diabetes appear to be a risk factor for cancer and is associated with the mortality risk in cancer patients, several factors such as diabetes duration, multiple drug therapy, and the presence of diabetes comorbidities make the assessment of the effect of diabetes treatment on cancer risk and mortality difficult. Metformin is the drug of choice for the treatment of type 2 diabetes. The available evidence from basic science, clinical, and population-based research supports the anticancer effect of metformin. However, randomized controlled clinical trials do not provide enough evidence for a strong protective effect of metformin on cancer incidence or mortality. One of the most important limitations of these trials is the short duration of the followup. Further long-term randomized controlled clinical trials specifically designed to determine metformin effect on cancer risk are needed to provide the best answer to this challenge. Hindawi Publishing Corporation 2013-09-24 /pmc/articles/PMC3800579/ /pubmed/24224094 http://dx.doi.org/10.1155/2013/636927 Text en Copyright © 2013 Mojtaba Malek et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Malek, Mojtaba
Aghili, Rokhsareh
Emami, Zahra
Khamseh, Mohammad E.
Risk of Cancer in Diabetes: The Effect of Metformin
title Risk of Cancer in Diabetes: The Effect of Metformin
title_full Risk of Cancer in Diabetes: The Effect of Metformin
title_fullStr Risk of Cancer in Diabetes: The Effect of Metformin
title_full_unstemmed Risk of Cancer in Diabetes: The Effect of Metformin
title_short Risk of Cancer in Diabetes: The Effect of Metformin
title_sort risk of cancer in diabetes: the effect of metformin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800579/
https://www.ncbi.nlm.nih.gov/pubmed/24224094
http://dx.doi.org/10.1155/2013/636927
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