Cargando…

[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF-κB/Snail Signal Transduction Pathway

To study the effects of [6]-gingerol, a ginger phytochemical, on tight junction (TJ) molecules, we investigated TJ tightening and signal transduction pathways in human pancreatic duct cell-derived cancer cell line PANC-1. The following methods were utilized: MTT assay to determine cytotoxicity; zymo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sung Ok, Kim, Mi Ryeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800596/ https://www.ncbi.nlm.nih.gov/pubmed/24204396 http://dx.doi.org/10.1155/2013/761852

Ejemplares similares

Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly
por: Weng, Mo, et al.
Publicado: (2016)

Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis
por: Song, Honghai, et al.
Publicado: (2020)

Anti-Wrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF-κB Signaling
por: Kim, So Ra, et al.
Publicado: (2013)

Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
por: Tsai, Jong-Rung, et al.
Publicado: (2015)

NF-κB and Snail1a coordinate the cell cycle with gastrulation
por: Liu, Xiaolin, et al.
Publicado: (2009)

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
por: Liou, Geou-Yarh, et al.
Publicado: (2013)

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
por: Cheng, Hsin-Lin, et al.
Publicado: (2016)

Luteolin reduces inflammation in Staphylococcus aureus-induced mastitis by inhibiting NF-κB activation and MMPs expression
por: Guo, Ying-fang, et al.
Publicado: (2017)

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
por: Wu, Y, et al.
Publicado: (2010)

Microtubules regulate disassembly of epithelial apical junctions
por: Ivanov, Andrei I, et al.
Publicado: (2006)

LKB1 suppresses glioma cell invasion via NF-κB/Snail signaling repression
por: Yuan, Ye, et al.
Publicado: (2019)

Matrix Metalloproteinases (MMPs) and Inhibitors of MMPs in the Avian Reproductive System: An Overview
por: Hrabia, Anna
Publicado: (2021)

6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK1/2-NF-κB Pathway
por: Zhang, Weiyue, et al.
Publicado: (2019)

Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes
por: Chen, Chanjuan, et al.
Publicado: (2023)

Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway
por: Han, Dan, et al.
Publicado: (2015)

IL-17A Promotes the Migration and Invasiveness of Cervical Cancer Cells by Coordinately Activating MMPs Expression via the p38/NF-κB Signal Pathway
por: Feng, Minjuan, et al.
Publicado: (2014)

MMPs rearrange DNA
por: LeBrasseur, Nicole
Publicado: (2005)

Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters
por: Ng, Mei Rosa, et al.
Publicado: (2014)

NF-κB–Dependent Snail Expression Promotes Epithelial–Mesenchymal Transition in Mastitis
por: Liu, Haokun, et al.
Publicado: (2021)

Differential Role of ERK and p38 on NF-κB Activation in Helicobacter pylori-Infected Gastric Epithelial Cells
por: Seo, Ji Hye, et al.
Publicado: (2013)

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status
por: Chi, Yuan, et al.
Publicado: (2016)

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail
por: Cichon, Magdalena A., et al.
Publicado: (2014)

Sources of dynamic variability in NF-κB signal transduction: A mechanistic model
por: Mothes, Janina, et al.
Publicado: (2015)

Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition
por: Mali, Aniket V., et al.
Publicado: (2018)

A Labile Pool of IQGAP1 Disassembles Endothelial Adherens Junctions
por: Yuan, Zhiguo, et al.
Publicado: (2013)

Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Communication through Inactivation of NF-κB
por: Rakib, Md. Abdur, et al.
Publicado: (2013)

miR-200a contributes to the migration of BMSCs induced by the secretions of E. faecalis via FOXJ1/NFκB/MMPs axis
por: Li, Mingwei, et al.
Publicado: (2020)

Correction: Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters
por: Ng, Mei Rosa, et al.
Publicado: (2015)

RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation
por: Cho, Jung Hee, et al.
Publicado: (2018)

Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma
por: Qin, Yuan, et al.
Publicado: (2016)

Ca++-dependent disassembly and reassembly of occluding junctions in guinea pig pancreatic acinar cells. Effect of drugs
Publicado: (1978)

Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
por: Lee, Eun Byeol, et al.
Publicado: (2018)

Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway
por: Tong, Jiafeng, et al.
Publicado: (2019)

Zhuanggu Guanjie herbal formula mitigates osteoarthritis via the NF-κB transduction mechanism
por: Guowei, Gong, et al.
Publicado: (2022)

Treponema pallidum protein Tp0136 promoting MMPs/TIMPs imbalance via PI3K, MAPK and NF-κB signalling pathways in HDVSMCs
por: Cai, Chun-Xiang, et al.
Publicado: (2022)

Actinomyosin Contraction, Phosphorylation of VE-Cadherin, and Actin Remodeling Enable Melanoma-Induced Endothelial Cell-Cell Junction Disassembly
por: Weidert, Eric, et al.
Publicado: (2014)

Computer aided gene mining for gingerol biosynthesis
por: James, Priyanka, et al.
Publicado: (2015)

Antineutrophil properties of natural gingerols in models of lupus
por: Ali, Ramadan A., et al.
Publicado: (2021)

Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain
por: Zhou, Bo, et al.
Publicado: (2015)

Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells
por: Li, Xiao-Hong, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_teat95925sj2ljdiqk7821pv0a