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Olfactory Dysfunction in Patients with Neuromyelitis Optica

Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory functio...

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Autores principales: Schmidt, Felix, Göktas, Önder, Jarius, Sven, Wildemann, Brigitte, Ruprecht, Klemens, Paul, Friedemann, Harms, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800619/
https://www.ncbi.nlm.nih.gov/pubmed/24187622
http://dx.doi.org/10.1155/2013/654501
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author Schmidt, Felix
Göktas, Önder
Jarius, Sven
Wildemann, Brigitte
Ruprecht, Klemens
Paul, Friedemann
Harms, Lutz
author_facet Schmidt, Felix
Göktas, Önder
Jarius, Sven
Wildemann, Brigitte
Ruprecht, Klemens
Paul, Friedemann
Harms, Lutz
author_sort Schmidt, Felix
collection PubMed
description Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). Methods. Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. Results. Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. Conclusions. Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO.
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spelling pubmed-38006192013-11-03 Olfactory Dysfunction in Patients with Neuromyelitis Optica Schmidt, Felix Göktas, Önder Jarius, Sven Wildemann, Brigitte Ruprecht, Klemens Paul, Friedemann Harms, Lutz Mult Scler Int Research Article Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). Methods. Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. Results. Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. Conclusions. Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO. Hindawi Publishing Corporation 2013 2013-09-25 /pmc/articles/PMC3800619/ /pubmed/24187622 http://dx.doi.org/10.1155/2013/654501 Text en Copyright © 2013 Felix Schmidt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Schmidt, Felix
Göktas, Önder
Jarius, Sven
Wildemann, Brigitte
Ruprecht, Klemens
Paul, Friedemann
Harms, Lutz
Olfactory Dysfunction in Patients with Neuromyelitis Optica
title Olfactory Dysfunction in Patients with Neuromyelitis Optica
title_full Olfactory Dysfunction in Patients with Neuromyelitis Optica
title_fullStr Olfactory Dysfunction in Patients with Neuromyelitis Optica
title_full_unstemmed Olfactory Dysfunction in Patients with Neuromyelitis Optica
title_short Olfactory Dysfunction in Patients with Neuromyelitis Optica
title_sort olfactory dysfunction in patients with neuromyelitis optica
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800619/
https://www.ncbi.nlm.nih.gov/pubmed/24187622
http://dx.doi.org/10.1155/2013/654501
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