PA01.63. Scientific evaluation on Siddha drug G 7 for the management of allergic disorders of the skin

PURPOSE: In the ancient siddha literature various herbomineral components individually and in combination are documented to have wide spectrum of activity against allergic disorders of skin like pruritus, urticaria, eczema etc. The aim of the present study was to establish the effect of G7 on IL 8, IL alpha 1 and histamine both in vivo and in vitro studies. METHOD: The cultured keratinocytes were exposed to uv irradiation and the release of IL 8, IL alpha 1 and histamine were established by ELISA. The effect of G7 on histamine induced wheel and flare reaction were established in human subjects. Capasicin and substance P were used as positive control with intra dermal histamine. RESULT: G7 had significantly interfered in the release of IL 8, IL alpha 1 and histamine in vitro studies and in vivo studies G7 had significantly reduced wheal and flare reaction in human subjects. CONCLUSION: The findings of the study have clearly established the anti-allergic effect of G7 and its mechanism of action. Siddha system of medicine was contemporary to ayurvedic system of medicine. Siddha system however was confined to Tamil nadu while the ayurvedic system was prevalent throughout India.