OA01.20. Enhanced hepatoprotective activity of piperine loaded optimised chitosan microspheres

PURPOSE: To convert natural origin drug into targeted drug delivery system, optimising the dosage form (microspheres containing natural drug) to procure the best dosage form of prepration and to aim a targeted site (liver) so as the maximum amount of drug can reach the targeted site with the outmost motto to achieve the maximum therapeutic efeect at desired site (liver) and the desired aim to avoid the adverse reaction of synthetic drugs system. METHOD: Method employed is that procurement of drug, followed by extracting its particular compound, evaluation and characterisation, then proceeds to convert into targeted drug delivery system, followed by optimization of dosage form, then proceeds to pharmacological process of liver targetting. RESULT: By loading natural drug into optimised targeted drug delivery system, a remarkable result has been achieved by analysing SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvic transaminase) and Histopathology profile. CONCLUSION: The outmost conclusion is that the natural origin drug when convert into targeted drug delivery shows significant and remarkable hepatoprotective activity which opens the new era of treating many hepatic diseases with the foremost aim of avoiding adverse effect of drugs, thus ayurveda proving its utility again in this moder age of medicinal world.