Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata

Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9,11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9,11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft c...

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Autores principales: Tseng, Yen-Ju, Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801121/
https://www.ncbi.nlm.nih.gov/pubmed/23985899
http://dx.doi.org/10.3390/md11093288
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author Tseng, Yen-Ju
Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Tseng, Yen-Ju
Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Tseng, Yen-Ju
collection PubMed
description Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9,11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9,11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 1–4 and its cytotoxicity against selected cell lines were evaluated.
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spelling pubmed-38011212013-10-22 Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata Tseng, Yen-Ju Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9,11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9,11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 1–4 and its cytotoxicity against selected cell lines were evaluated. MDPI 2013-08-27 /pmc/articles/PMC3801121/ /pubmed/23985899 http://dx.doi.org/10.3390/md11093288 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tseng, Yen-Ju
Wang, Shang-Kwei
Duh, Chang-Yih
Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title_full Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title_fullStr Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title_full_unstemmed Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title_short Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
title_sort secosteroids and norcembranoids from the soft coral sinularia nanolobata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801121/
https://www.ncbi.nlm.nih.gov/pubmed/23985899
http://dx.doi.org/10.3390/md11093288
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