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Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem
When the microtubule (MT)-associated protein tau is not bound to axonal MTs, it becomes hyperphosphorylated and vulnerable to proteolytic cleavage and other changes typically seen in the hallmark tau deposits (neurofibrillary tangles) of tau-associated neurodegenerative diseases (tauopathies). Neuro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801151/ https://www.ncbi.nlm.nih.gov/pubmed/24151487 http://dx.doi.org/10.3389/fneur.2013.00160 |