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Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation
Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty ac...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803126/ https://www.ncbi.nlm.nih.gov/pubmed/24191156 http://dx.doi.org/10.1155/2013/120475 |
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author | Costa, Adilson Siqueira Talarico, Aline Parra Duarte, Carla de Oliveira Silva Pereira, Caroline de Souza Weimann, Ellem Tatiani Sabino de Matos, Lissa Della Coletta, Livia Carolina Fidelis, Maria Carolina Tannous, Thaísa Saddi Vasconcellos, Cidia |
author_facet | Costa, Adilson Siqueira Talarico, Aline Parra Duarte, Carla de Oliveira Silva Pereira, Caroline de Souza Weimann, Ellem Tatiani Sabino de Matos, Lissa Della Coletta, Livia Carolina Fidelis, Maria Carolina Tannous, Thaísa Saddi Vasconcellos, Cidia |
author_sort | Costa, Adilson |
collection | PubMed |
description | Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids' chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris. |
format | Online Article Text |
id | pubmed-3803126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38031262013-11-04 Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation Costa, Adilson Siqueira Talarico, Aline Parra Duarte, Carla de Oliveira Silva Pereira, Caroline de Souza Weimann, Ellem Tatiani Sabino de Matos, Lissa Della Coletta, Livia Carolina Fidelis, Maria Carolina Tannous, Thaísa Saddi Vasconcellos, Cidia Dermatol Res Pract Clinical Study Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids' chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3803126/ /pubmed/24191156 http://dx.doi.org/10.1155/2013/120475 Text en Copyright © 2013 Adilson Costa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Costa, Adilson Siqueira Talarico, Aline Parra Duarte, Carla de Oliveira Silva Pereira, Caroline de Souza Weimann, Ellem Tatiani Sabino de Matos, Lissa Della Coletta, Livia Carolina Fidelis, Maria Carolina Tannous, Thaísa Saddi Vasconcellos, Cidia Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title_full | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title_fullStr | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title_full_unstemmed | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title_short | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
title_sort | evaluation of the quantitative and qualitative alterations in the fatty acid contents of the sebum of patients with inflammatory acne during treatment with systemic lymecycline and/or oral fatty acid supplementation |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803126/ https://www.ncbi.nlm.nih.gov/pubmed/24191156 http://dx.doi.org/10.1155/2013/120475 |
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