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AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the A...

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Detalles Bibliográficos
Autores principales:	Haskin, Joseph, Szargel, Raymonde, Shani, Vered, Mekies, Lucy N., Rott, Ruth, Lim, Grace G. Y., Lim, Kah-Leong, Bandopadhyay, Rina, Wolosker, Herman, Engelender, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803144/ https://www.ncbi.nlm.nih.gov/pubmed/23393160 http://dx.doi.org/10.1093/hmg/ddt058

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