Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation

Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-...

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Autores principales: Oktay, Esin, Yersal, Özlem, Meydan, Nezih, Sağıroğlu, Mehmet, Uyanık, Ömer, Barutca, Sabri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804136/
https://www.ncbi.nlm.nih.gov/pubmed/24191208
http://dx.doi.org/10.1155/2013/234391
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author Oktay, Esin
Yersal, Özlem
Meydan, Nezih
Sağıroğlu, Mehmet
Uyanık, Ömer
Barutca, Sabri
author_facet Oktay, Esin
Yersal, Özlem
Meydan, Nezih
Sağıroğlu, Mehmet
Uyanık, Ömer
Barutca, Sabri
author_sort Oktay, Esin
collection PubMed
description Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine.
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spelling pubmed-38041362013-11-04 Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation Oktay, Esin Yersal, Özlem Meydan, Nezih Sağıroğlu, Mehmet Uyanık, Ömer Barutca, Sabri Case Rep Oncol Med Case Report Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3804136/ /pubmed/24191208 http://dx.doi.org/10.1155/2013/234391 Text en Copyright © 2013 Esin Oktay et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oktay, Esin
Yersal, Özlem
Meydan, Nezih
Sağıroğlu, Mehmet
Uyanık, Ömer
Barutca, Sabri
Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title_full Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title_fullStr Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title_full_unstemmed Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title_short Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
title_sort nearly complete response of brain metastases from her2 overexpressing breast cancer with lapatinib and capecitabine after whole brain irradiation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804136/
https://www.ncbi.nlm.nih.gov/pubmed/24191208
http://dx.doi.org/10.1155/2013/234391
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