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Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues

Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (i...

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Autores principales: Son, Yong, Lee, Ju Hwan, Cheong, Yong-Kwan, Chung, Hun-Taeg, Pae, Hyun-Ock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804143/
https://www.ncbi.nlm.nih.gov/pubmed/24191253
http://dx.doi.org/10.1155/2013/918039
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author Son, Yong
Lee, Ju Hwan
Cheong, Yong-Kwan
Chung, Hun-Taeg
Pae, Hyun-Ock
author_facet Son, Yong
Lee, Ju Hwan
Cheong, Yong-Kwan
Chung, Hun-Taeg
Pae, Hyun-Ock
author_sort Son, Yong
collection PubMed
description Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of diabetes, agents and cellular molecules that can modulate these stress responses are emerging as potential targets for intervention and treatment of diabetic diseases. It has been recognized that heme oxygenase-1 (HO-1) plays an important role in cellular protection. Because HO-1 can reduce oxidative stress, inflammatory stress, and ER stress, in part by exerting antioxidant, anti-inflammatory, and antiapoptotic effects, HO-1 has been suggested to play important roles in pathogenesis of diabetes. In the present review, we will explore our current understanding of the protective mechanisms of HO-1 in diabetes and present some emerging therapeutic options for HO-1 expression in treating diabetic diseases, together with the therapeutic potential of curcumin analogues that have their ability to induce HO-1 expression.
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spelling pubmed-38041432013-11-04 Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues Son, Yong Lee, Ju Hwan Cheong, Yong-Kwan Chung, Hun-Taeg Pae, Hyun-Ock Biomed Res Int Review Article Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of diabetes, agents and cellular molecules that can modulate these stress responses are emerging as potential targets for intervention and treatment of diabetic diseases. It has been recognized that heme oxygenase-1 (HO-1) plays an important role in cellular protection. Because HO-1 can reduce oxidative stress, inflammatory stress, and ER stress, in part by exerting antioxidant, anti-inflammatory, and antiapoptotic effects, HO-1 has been suggested to play important roles in pathogenesis of diabetes. In the present review, we will explore our current understanding of the protective mechanisms of HO-1 in diabetes and present some emerging therapeutic options for HO-1 expression in treating diabetic diseases, together with the therapeutic potential of curcumin analogues that have their ability to induce HO-1 expression. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3804143/ /pubmed/24191253 http://dx.doi.org/10.1155/2013/918039 Text en Copyright © 2013 Yong Son et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Son, Yong
Lee, Ju Hwan
Cheong, Yong-Kwan
Chung, Hun-Taeg
Pae, Hyun-Ock
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title_full Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title_fullStr Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title_full_unstemmed Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title_short Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
title_sort antidiabetic potential of the heme oxygenase-1 inducer curcumin analogues
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804143/
https://www.ncbi.nlm.nih.gov/pubmed/24191253
http://dx.doi.org/10.1155/2013/918039
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