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Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1
Altered functions of the lung epithelial surface likely contribute to the respiratory morbidities in infants with bronchopulmonary dysplasia (BPD). Infants with BPD exhibit decreased expressions of secretoglobins (SCGBs), including Clara cell secretory protein (CCSP). Expression of lung SCGB and ann...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804154/ https://www.ncbi.nlm.nih.gov/pubmed/24187664 http://dx.doi.org/10.1155/2013/408485 |
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author | Raffay, Thomas M. Locy, Morgan L. Hill, Cynthia L. Jindal, Nik S. Rogers, Lynette K. Welty, Stephen E. Tipple, Trent E. |
author_facet | Raffay, Thomas M. Locy, Morgan L. Hill, Cynthia L. Jindal, Nik S. Rogers, Lynette K. Welty, Stephen E. Tipple, Trent E. |
author_sort | Raffay, Thomas M. |
collection | PubMed |
description | Altered functions of the lung epithelial surface likely contribute to the respiratory morbidities in infants with bronchopulmonary dysplasia (BPD). Infants with BPD exhibit decreased expressions of secretoglobins (SCGBs), including Clara cell secretory protein (CCSP). Expression of lung SCGB and annexin A1 (ANXA1) is persistently altered in CCSP knockout mice suggesting that CCSP indirectly influences innate immune responses. The present studies tested the hypothesis that neonatal hyperoxic exposure induces deficits in CCSP expression that are associated with persistent alterations in lung SCGB and ANXA1 expression. Newborn C3H/HeN mice were exposed to room air (RA) or 85% O(2) from birth and were sacrificed at 14 d or returned to RA for 14 d. Neonatal hyperoxia followed by RA recovery was associated with decreased lung CCSP and SCGB3A1 protein but not mRNA expression. Hyperoxia-induced alterations in the charge characteristics of ANXA1 were unchanged by RA recovery and were associated with elevated lung macrophage numbers. These findings support a model in which hyperoxia-induced alterations in Clara cell function influence lung innate immune function through effects on immunomodulatory proteins. Studies to determine the mechanism(s) by which CCSP alterations affect SCGBs, ANXA1, and innate immune responses in BPD are warranted. |
format | Online Article Text |
id | pubmed-3804154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38041542013-11-03 Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 Raffay, Thomas M. Locy, Morgan L. Hill, Cynthia L. Jindal, Nik S. Rogers, Lynette K. Welty, Stephen E. Tipple, Trent E. Biomed Res Int Research Article Altered functions of the lung epithelial surface likely contribute to the respiratory morbidities in infants with bronchopulmonary dysplasia (BPD). Infants with BPD exhibit decreased expressions of secretoglobins (SCGBs), including Clara cell secretory protein (CCSP). Expression of lung SCGB and annexin A1 (ANXA1) is persistently altered in CCSP knockout mice suggesting that CCSP indirectly influences innate immune responses. The present studies tested the hypothesis that neonatal hyperoxic exposure induces deficits in CCSP expression that are associated with persistent alterations in lung SCGB and ANXA1 expression. Newborn C3H/HeN mice were exposed to room air (RA) or 85% O(2) from birth and were sacrificed at 14 d or returned to RA for 14 d. Neonatal hyperoxia followed by RA recovery was associated with decreased lung CCSP and SCGB3A1 protein but not mRNA expression. Hyperoxia-induced alterations in the charge characteristics of ANXA1 were unchanged by RA recovery and were associated with elevated lung macrophage numbers. These findings support a model in which hyperoxia-induced alterations in Clara cell function influence lung innate immune function through effects on immunomodulatory proteins. Studies to determine the mechanism(s) by which CCSP alterations affect SCGBs, ANXA1, and innate immune responses in BPD are warranted. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3804154/ /pubmed/24187664 http://dx.doi.org/10.1155/2013/408485 Text en Copyright © 2013 Thomas M. Raffay et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Raffay, Thomas M. Locy, Morgan L. Hill, Cynthia L. Jindal, Nik S. Rogers, Lynette K. Welty, Stephen E. Tipple, Trent E. Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title | Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title_full | Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title_fullStr | Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title_full_unstemmed | Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title_short | Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1 |
title_sort | neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin a1 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804154/ https://www.ncbi.nlm.nih.gov/pubmed/24187664 http://dx.doi.org/10.1155/2013/408485 |
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