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Maturation and Emigration of Single-Positive Thymocytes

T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocyte...

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Detalles Bibliográficos
Autores principales: Xu, Xi, Zhang, Shusong, Li, Pingping, Lu, Jin, Xuan, Qun, Ge, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804360/
https://www.ncbi.nlm.nih.gov/pubmed/24187562
http://dx.doi.org/10.1155/2013/282870
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author Xu, Xi
Zhang, Shusong
Li, Pingping
Lu, Jin
Xuan, Qun
Ge, Qing
author_facet Xu, Xi
Zhang, Shusong
Li, Pingping
Lu, Jin
Xuan, Qun
Ge, Qing
author_sort Xu, Xi
collection PubMed
description T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.
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spelling pubmed-38043602013-11-03 Maturation and Emigration of Single-Positive Thymocytes Xu, Xi Zhang, Shusong Li, Pingping Lu, Jin Xuan, Qun Ge, Qing Clin Dev Immunol Review Article T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed. Hindawi Publishing Corporation 2013 2013-09-29 /pmc/articles/PMC3804360/ /pubmed/24187562 http://dx.doi.org/10.1155/2013/282870 Text en Copyright © 2013 Xi Xu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Xi
Zhang, Shusong
Li, Pingping
Lu, Jin
Xuan, Qun
Ge, Qing
Maturation and Emigration of Single-Positive Thymocytes
title Maturation and Emigration of Single-Positive Thymocytes
title_full Maturation and Emigration of Single-Positive Thymocytes
title_fullStr Maturation and Emigration of Single-Positive Thymocytes
title_full_unstemmed Maturation and Emigration of Single-Positive Thymocytes
title_short Maturation and Emigration of Single-Positive Thymocytes
title_sort maturation and emigration of single-positive thymocytes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804360/
https://www.ncbi.nlm.nih.gov/pubmed/24187562
http://dx.doi.org/10.1155/2013/282870
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