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Maturation and Emigration of Single-Positive Thymocytes
T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocyte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804360/ https://www.ncbi.nlm.nih.gov/pubmed/24187562 http://dx.doi.org/10.1155/2013/282870 |
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author | Xu, Xi Zhang, Shusong Li, Pingping Lu, Jin Xuan, Qun Ge, Qing |
author_facet | Xu, Xi Zhang, Shusong Li, Pingping Lu, Jin Xuan, Qun Ge, Qing |
author_sort | Xu, Xi |
collection | PubMed |
description | T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed. |
format | Online Article Text |
id | pubmed-3804360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38043602013-11-03 Maturation and Emigration of Single-Positive Thymocytes Xu, Xi Zhang, Shusong Li, Pingping Lu, Jin Xuan, Qun Ge, Qing Clin Dev Immunol Review Article T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed. Hindawi Publishing Corporation 2013 2013-09-29 /pmc/articles/PMC3804360/ /pubmed/24187562 http://dx.doi.org/10.1155/2013/282870 Text en Copyright © 2013 Xi Xu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xu, Xi Zhang, Shusong Li, Pingping Lu, Jin Xuan, Qun Ge, Qing Maturation and Emigration of Single-Positive Thymocytes |
title | Maturation and Emigration of Single-Positive Thymocytes |
title_full | Maturation and Emigration of Single-Positive Thymocytes |
title_fullStr | Maturation and Emigration of Single-Positive Thymocytes |
title_full_unstemmed | Maturation and Emigration of Single-Positive Thymocytes |
title_short | Maturation and Emigration of Single-Positive Thymocytes |
title_sort | maturation and emigration of single-positive thymocytes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804360/ https://www.ncbi.nlm.nih.gov/pubmed/24187562 http://dx.doi.org/10.1155/2013/282870 |
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