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Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats
INTRODUCTION: Coronary heart disease and hyperlipidemia is a global problem in today’s world. A large number of people suffer from hypertension, atherosclerosis and all these has strong association with the hyperlipidemia. There are many drugs for the treatment of hyperlipidemia, but statins are mos...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AVICENA, d.o.o., Sarajevo
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804389/ https://www.ncbi.nlm.nih.gov/pubmed/24167434 http://dx.doi.org/10.5455/msm.2013.25.192-195 |
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author | Prasad, Anju Pratim Datta, Pratyay Roy, Ritesh Pattanayak, Chaitali Panda, Parbaty |
author_facet | Prasad, Anju Pratim Datta, Pratyay Roy, Ritesh Pattanayak, Chaitali Panda, Parbaty |
author_sort | Prasad, Anju |
collection | PubMed |
description | INTRODUCTION: Coronary heart disease and hyperlipidemia is a global problem in today’s world. A large number of people suffer from hypertension, atherosclerosis and all these has strong association with the hyperlipidemia. There are many drugs for the treatment of hyperlipidemia, but statins are most commonly used. But, with high dose of statins, the side effect is also there which restricts its use in high dose. Ezetimibe is a comparatively new drug for the treatment of hyperlipidemia having lesser adverse effect as compared to statin. This study has been planned to find out the comparative efficacy of Ezetimibe and Atorvastatin alone and in combination on the lipid profile in rats. METHODOLOGY: This study was conducted in SCB Medical College, Cuttack. 60 rats were fed on atherogenic diet. These were divided in six groups having ten rats in each group and followed for 12 weeks. Group I received only atherogenic diet. All other groups received drugs after four weeks. Group II received Ezetimibe 1mg/kg, Group III received Ezetimibe 2mg/kg, Group IV received Atorvastatin 4mg/kg, Group V received Atorvastatin 8mg/kg and Group VI received Atorvastatin 4mg/kg and Ezetimibe 1mg/kg. Blood lipid profile measured at zero week, four weeks and 12 weeks. RESULTS: All the lipid profile parameters improved significantly with treatment groups as compared with control group. There was no significant difference in the level of different lipid parameters between Group V (Atorvastatin 8mg/kg) and Group VI (Atorvastatin 4mg/kg and Ezetimibe 1mg/kg). CONCLUSION: High dose of Atorvastatin is associated with more adverse effect. The efficacy of high dose of Atorvastatin is comparable to combination of low dose Atorvastatin with Ezetimibe. This combination has lesser side effects. So, this can be a good alternative. |
format | Online Article Text |
id | pubmed-3804389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | AVICENA, d.o.o., Sarajevo |
record_format | MEDLINE/PubMed |
spelling | pubmed-38043892013-10-28 Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats Prasad, Anju Pratim Datta, Pratyay Roy, Ritesh Pattanayak, Chaitali Panda, Parbaty Mater Sociomed Original Paper INTRODUCTION: Coronary heart disease and hyperlipidemia is a global problem in today’s world. A large number of people suffer from hypertension, atherosclerosis and all these has strong association with the hyperlipidemia. There are many drugs for the treatment of hyperlipidemia, but statins are most commonly used. But, with high dose of statins, the side effect is also there which restricts its use in high dose. Ezetimibe is a comparatively new drug for the treatment of hyperlipidemia having lesser adverse effect as compared to statin. This study has been planned to find out the comparative efficacy of Ezetimibe and Atorvastatin alone and in combination on the lipid profile in rats. METHODOLOGY: This study was conducted in SCB Medical College, Cuttack. 60 rats were fed on atherogenic diet. These were divided in six groups having ten rats in each group and followed for 12 weeks. Group I received only atherogenic diet. All other groups received drugs after four weeks. Group II received Ezetimibe 1mg/kg, Group III received Ezetimibe 2mg/kg, Group IV received Atorvastatin 4mg/kg, Group V received Atorvastatin 8mg/kg and Group VI received Atorvastatin 4mg/kg and Ezetimibe 1mg/kg. Blood lipid profile measured at zero week, four weeks and 12 weeks. RESULTS: All the lipid profile parameters improved significantly with treatment groups as compared with control group. There was no significant difference in the level of different lipid parameters between Group V (Atorvastatin 8mg/kg) and Group VI (Atorvastatin 4mg/kg and Ezetimibe 1mg/kg). CONCLUSION: High dose of Atorvastatin is associated with more adverse effect. The efficacy of high dose of Atorvastatin is comparable to combination of low dose Atorvastatin with Ezetimibe. This combination has lesser side effects. So, this can be a good alternative. AVICENA, d.o.o., Sarajevo 2013 /pmc/articles/PMC3804389/ /pubmed/24167434 http://dx.doi.org/10.5455/msm.2013.25.192-195 Text en © 2013 AVICENA http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Prasad, Anju Pratim Datta, Pratyay Roy, Ritesh Pattanayak, Chaitali Panda, Parbaty Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title | Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title_full | Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title_fullStr | Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title_full_unstemmed | Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title_short | Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats |
title_sort | comparative study of ezetimibe and atorvastatin alone and in combination on lipid profile in rats |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804389/ https://www.ncbi.nlm.nih.gov/pubmed/24167434 http://dx.doi.org/10.5455/msm.2013.25.192-195 |
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