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Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience
INTRODUCTION: Clostridium difficile (C. difficile) is currently the leading cause of healthcare-associated diarrhea, but almost nothing is known about the extent of C. difficile infection (CDI) in Bosnia and Herzegovina. GOAL: We aimed to retrospectively analyze CDI in hospitalized patients at Unive...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AVICENA, d.o.o., Sarajevo
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804390/ https://www.ncbi.nlm.nih.gov/pubmed/24167425 http://dx.doi.org/10.5455/msm.2013.25.153-157 |
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author | Ahmetagic, Sead Salkic, Nermin Ahmetagic, Aldina Custovic, Amer Tihic, Nijaz Smajlovic, Jasmina Porobic-Jahic, Humera |
author_facet | Ahmetagic, Sead Salkic, Nermin Ahmetagic, Aldina Custovic, Amer Tihic, Nijaz Smajlovic, Jasmina Porobic-Jahic, Humera |
author_sort | Ahmetagic, Sead |
collection | PubMed |
description | INTRODUCTION: Clostridium difficile (C. difficile) is currently the leading cause of healthcare-associated diarrhea, but almost nothing is known about the extent of C. difficile infection (CDI) in Bosnia and Herzegovina. GOAL: We aimed to retrospectively analyze CDI in hospitalized patients at University Clinical Center (UCC) Tuzla, Bosnia and Herzegovina from January 2009 through June 2012. METHODS: We analyzed all patients (except children ages 0-2), diagnosed with CDI based on anamnestic and epidemiological, clinical picture and microbiological tests (proof of toxins in the stool by enzyme-linked immunosorbent assay). RESULTS: From a total of 989 patients tested for C. difficile toxin (60.2 per 10,000 inpatient days) 347 (35.08%) were positives. The mean incidence rate of CDI was 2.23 per 10,000 inpatient days (range 1.32-2.87). Annual rates of hospitalization were 15.68 per 10,000 admissions (range 8.99-20.35). Most patients had a previously identified risk profile of old age, comorbidity and recent use of antibiotics. 41/276 (14.86%) patients had died, and 11/41 (26.82%) were CDI-associated deaths. Complicated CDI were registered in 53/276 (19.21%) patients, and recurrent infections in 65/276 (23.55%). CONCLUSION: Our data suggest that CDI is largely present in our setting which represents a serious problem and points to the importance of international surveillance, detection and control of CDI. |
format | Online Article Text |
id | pubmed-3804390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | AVICENA, d.o.o., Sarajevo |
record_format | MEDLINE/PubMed |
spelling | pubmed-38043902013-10-28 Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience Ahmetagic, Sead Salkic, Nermin Ahmetagic, Aldina Custovic, Amer Tihic, Nijaz Smajlovic, Jasmina Porobic-Jahic, Humera Mater Sociomed Original Paper INTRODUCTION: Clostridium difficile (C. difficile) is currently the leading cause of healthcare-associated diarrhea, but almost nothing is known about the extent of C. difficile infection (CDI) in Bosnia and Herzegovina. GOAL: We aimed to retrospectively analyze CDI in hospitalized patients at University Clinical Center (UCC) Tuzla, Bosnia and Herzegovina from January 2009 through June 2012. METHODS: We analyzed all patients (except children ages 0-2), diagnosed with CDI based on anamnestic and epidemiological, clinical picture and microbiological tests (proof of toxins in the stool by enzyme-linked immunosorbent assay). RESULTS: From a total of 989 patients tested for C. difficile toxin (60.2 per 10,000 inpatient days) 347 (35.08%) were positives. The mean incidence rate of CDI was 2.23 per 10,000 inpatient days (range 1.32-2.87). Annual rates of hospitalization were 15.68 per 10,000 admissions (range 8.99-20.35). Most patients had a previously identified risk profile of old age, comorbidity and recent use of antibiotics. 41/276 (14.86%) patients had died, and 11/41 (26.82%) were CDI-associated deaths. Complicated CDI were registered in 53/276 (19.21%) patients, and recurrent infections in 65/276 (23.55%). CONCLUSION: Our data suggest that CDI is largely present in our setting which represents a serious problem and points to the importance of international surveillance, detection and control of CDI. AVICENA, d.o.o., Sarajevo 2013 /pmc/articles/PMC3804390/ /pubmed/24167425 http://dx.doi.org/10.5455/msm.2013.25.153-157 Text en © 2013 AVICENA http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Ahmetagic, Sead Salkic, Nermin Ahmetagic, Aldina Custovic, Amer Tihic, Nijaz Smajlovic, Jasmina Porobic-Jahic, Humera Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title | Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title_full | Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title_fullStr | Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title_full_unstemmed | Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title_short | Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience |
title_sort | clostridium difficile infection in hospitalized patients at university clinical center tuzla, bosnia and herzegovina: a 4 year experience |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804390/ https://www.ncbi.nlm.nih.gov/pubmed/24167425 http://dx.doi.org/10.5455/msm.2013.25.153-157 |
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