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Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa

INTRODUCTION: Our purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa (RP). METHODS: Sixty-six eyes from 33 patients with RP and with different visual acuity (VA) were studied using optical coherence tomography (OCT) and multifocal elect...

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Autores principales: Moschos, Marilita M, Chatziralli, Irini P, Verriopoulos, George V, Triglianos, Aristeides, Ladas, Dimitrios S, Brouzas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804559/
https://www.ncbi.nlm.nih.gov/pubmed/24204109
http://dx.doi.org/10.2147/OPTH.S50752
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author Moschos, Marilita M
Chatziralli, Irini P
Verriopoulos, George V
Triglianos, Aristeides
Ladas, Dimitrios S
Brouzas, Dimitrios
author_facet Moschos, Marilita M
Chatziralli, Irini P
Verriopoulos, George V
Triglianos, Aristeides
Ladas, Dimitrios S
Brouzas, Dimitrios
author_sort Moschos, Marilita M
collection PubMed
description INTRODUCTION: Our purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa (RP). METHODS: Sixty-six eyes from 33 patients with RP and with different visual acuity (VA) were studied using optical coherence tomography (OCT) and multifocal electroretinogram (mfERG). Correlation analysis was performed between VA, macular thickness, mfERG amplitude, and latency. RESULTS: Retinal thickness, retinal response density, and latency of the mfERG in the foveal area were independently and positively associated with VA (P = 0.002; P < 0.0001; P = 0.029; and P = 0.002, respectively), whereas there was no evidence for a correlation between VA and the amplitude of mfERG in the parafoveal area. Evidence of a correlation between the OCT and the mfERG evaluation was of borderline significance (P = 0.047). Also, there was evidence for an inverse association of VA with latency in ring 1 and ring 2 (b = −0.138; 95% confidence interval: −0.261, −0.015; P = 0.029). In accordance with the univariate findings, when foveal retinal thickness, mfERG amplitude, and latency in ring 1 were inserted simultaneously in the same model, all the three variables remained significantly associated with VA (P = 0.016; P < 0.0001; and P = 0.031, respectively). Nevertheless, some individual values deviated from the expected range. More specifically, 15 eyes showed a normal retinal thickness, whereas the respective VA was relatively low and the mfERG values were abnormal. Conversely, in seven eyes, despite the low retinal thickness, the respective VA was high. CONCLUSION: The combined use of OCT with mfERG appears to be more appropriate for the estimation of macular function.
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spelling pubmed-38045592013-11-07 Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa Moschos, Marilita M Chatziralli, Irini P Verriopoulos, George V Triglianos, Aristeides Ladas, Dimitrios S Brouzas, Dimitrios Clin Ophthalmol Original Research INTRODUCTION: Our purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa (RP). METHODS: Sixty-six eyes from 33 patients with RP and with different visual acuity (VA) were studied using optical coherence tomography (OCT) and multifocal electroretinogram (mfERG). Correlation analysis was performed between VA, macular thickness, mfERG amplitude, and latency. RESULTS: Retinal thickness, retinal response density, and latency of the mfERG in the foveal area were independently and positively associated with VA (P = 0.002; P < 0.0001; P = 0.029; and P = 0.002, respectively), whereas there was no evidence for a correlation between VA and the amplitude of mfERG in the parafoveal area. Evidence of a correlation between the OCT and the mfERG evaluation was of borderline significance (P = 0.047). Also, there was evidence for an inverse association of VA with latency in ring 1 and ring 2 (b = −0.138; 95% confidence interval: −0.261, −0.015; P = 0.029). In accordance with the univariate findings, when foveal retinal thickness, mfERG amplitude, and latency in ring 1 were inserted simultaneously in the same model, all the three variables remained significantly associated with VA (P = 0.016; P < 0.0001; and P = 0.031, respectively). Nevertheless, some individual values deviated from the expected range. More specifically, 15 eyes showed a normal retinal thickness, whereas the respective VA was relatively low and the mfERG values were abnormal. Conversely, in seven eyes, despite the low retinal thickness, the respective VA was high. CONCLUSION: The combined use of OCT with mfERG appears to be more appropriate for the estimation of macular function. Dove Medical Press 2013 2013-10-16 /pmc/articles/PMC3804559/ /pubmed/24204109 http://dx.doi.org/10.2147/OPTH.S50752 Text en © 2013 Moschos et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Moschos, Marilita M
Chatziralli, Irini P
Verriopoulos, George V
Triglianos, Aristeides
Ladas, Dimitrios S
Brouzas, Dimitrios
Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title_full Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title_fullStr Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title_full_unstemmed Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title_short Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
title_sort correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804559/
https://www.ncbi.nlm.nih.gov/pubmed/24204109
http://dx.doi.org/10.2147/OPTH.S50752
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